Omicron variant showed lower neutralizing sensitivity than other SARS-CoV-2 variants to immune sera elicited by vaccines after boost

• Published in: Emerging microbes & infections Vol. 11; no. 1; pp. 337 - 343
• Main Authors: Ai, Jingwen, Zhang, Haocheng, Zhang, Yi, Lin, Ke, Zhang, Yanliang, Wu, Jing, Wan, Yanming, Huang, Yanfang, Song, Jieyu, Fu, Zhangfan, Wang, Hongyu, Guo, Jingxin, Jiang, Ning, Fan, Mingxiang, Zhou, Yang, Zhao, Yuanhan, Zhang, Qiran, Liu, Qiang, Lv, Jing, Li, Peiyao, Qiu, Chao, Zhang, Wenhong
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.12.2022; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Adult; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibodies, Viral - blood; Antibodies, Viral - immunology; Coronaviruses; Covid-19; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 - virology; COVID-19 Vaccines - administration & dosage; COVID-19 Vaccines - immunology; Female; Humans; Immune Sera - immunology; Immunization; Immunization, Secondary; Immunogenicity, Vaccine; Middle Aged; neutralizing antibody; Omicron; Pseudotyped viruses; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Vaccination; vaccine; Vaccines; Pseudotyped viruses; neutralizing antibody; vaccine; Omicron; Covid-19

The emerging new VOC B.1.1.529 (Omicron) variant has raised serious concerns due to multiple mutations, reported significant immune escape, and unprecedented rapid spreading speed. Currently, studies describing the neutralization ability of different homologous and heterologous booster vaccination a...