PCDH17 gene promoter methylation status in a cohort of Egyptian women with epithelial ovarian cancer

• Published in: BMC cancer Vol. 23; no. 1; pp. 89 - 10
• Main Authors: Elsharkawi, Sherif Mohamed, Elkaffash, Dalal, Moez, Pacint, El-Etreby, Nour, Sheta, Eman, Taleb, Raghda Saad Zaghloul
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25.01.2023; BioMed Central; BMC
• Subjects: Analysis; Annealing; Apoptosis; Cadherins; Cadherins - genetics; Carcinogenesis; Carcinoma, Ovarian Epithelial - genetics; Care and treatment; Cell adhesion; CpG islands; Diagnosis; DNA Methylation; Egypt; Epigenetics; Female; Females; Genes; Genetic aspects; Health aspects; Humans; Laboratories; Methylation; Oophorectomy; Ovarian cancer; Ovarian Cysts; Ovarian Neoplasms - genetics; Paraffin; PCDH17; Promoter Regions, Genetic; Promoters (Genetics); Protocadherin; Pyrosequencing; Software; Statistical analysis; Tumor suppressor genes; Work stations; Egypt; United States > US; Germany; DNA methylation; Epigenetics; PCDH17; Pyrosequencing; Ovarian cancer

Ovarian cancer is a leading cause of female mortality. Epigenetic changes occur in early stages of carcinogenesis and represent a marker for cancer diagnosis. Protocadherin 17 (PCDH17) is a tumor suppressor gene involved in cell adhesion and apoptosis. The methylation of PCDH17 gene promoter has bee...