A clinical transcriptome approach to patient stratification and therapy selection in acute myeloid leukemia

• Published in: Nature communications Vol. 12; no. 1; p. 2474
• Main Authors: Docking, T. Roderick, Parker, Jeremy D. K., Jädersten, Martin, Duns, Gerben, Chang, Linda, Jiang, Jihong, Pilsworth, Jessica A., Swanson, Lucas A., Chan, Simon K., Chiu, Readman, Nip, Ka Ming, Mar, Samantha, Mo, Angela, Wang, Xuan, Martinez-Høyer, Sergio, Stubbins, Ryan J., Mungall, Karen L., Mungall, Andrew J., Moore, Richard A., Jones, Steven J. M., Birol, İnanç, Marra, Marco A., Hogge, Donna, Karsan, Aly
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.04.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 38/1; 38/22; 38/39; 38/91; 45/100; 49/23; 49/90; 631/67/1990; 631/67/2322; 631/67/68; 631/67/69; 692/4028/67/1990/283/1897; 82/80; Acute myeloid leukemia; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cell Line, Tumor; Cohort Studies; Core Binding Factor Alpha 2 Subunit - genetics; Core Binding Factor Alpha 2 Subunit - metabolism; Female; Focal adhesion kinase; Gene deletion; Gene expression; Gene Expression Regulation, Neoplastic - genetics; Gene Fusion; Gene sequencing; Genetic screening; Genomics; Humanities and Social Sciences; Humans; INDEL Mutation; Insertion; Integrins - genetics; Integrins - metabolism; Kinases; Leukemia; Leukemia, Myeloid, Acute - diagnosis; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - metabolism; Male; Malignancy; Medicin och hälsovetenskap; multidisciplinary; Mutation; Myeloid leukemia; Nucleotides; p53 Protein; Patients; Polymorphism, Single Nucleotide; Prognosis; Prospective Studies; Ribonucleic acid; Risk; Risk Factors; Risk groups; RNA; RNA-Seq; Runx1 protein; Science; Science (multidisciplinary); Signal Transduction - genetics; Subgroups; Survival Analysis; Therapy; Transcriptome; Transcriptomes; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Whole Exome Sequencing; Whole Genome Sequencing

As more clinically-relevant genomic features of myeloid malignancies are revealed, it has become clear that targeted clinical genetic testing is inadequate for risk stratification. Here, we develop and validate a clinical transcriptome-based assay for stratification of acute myeloid leukemia (AML)....