Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review

• Published in: Journal of enzyme inhibition and medicinal chemistry Vol. 37; no. 1; pp. 2304 - 2319
• Main Authors: Wang, Jing-Jing, Sun, Wen, Jia, Wei-Dong, Bian, Ming, Yu, Li-Jun
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2022; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: 1,2,4-oxadiazole; 1,3,4-oxadiazole; activity; Analgesics; Anti-Bacterial Agents - pharmacology; Antifungal agents; Antioxidants; Binding sites; Biological activity; Cancer; Cell growth; Chemistry; Chemistry Techniques, Synthetic; Chemistry, Pharmaceutical; Diabetes; Diabetes mellitus; Enzymes; Inflammation; Kinases; Laboratories; Nonsteroidal anti-inflammatory drugs; Oxadiazole derivatives; Oxadiazoles - chemistry; Oxadiazoles - pharmacology; Pharmaceutical sciences; Pharmacokinetics; Pharmacology; Review; synthesis; synthesis; Oxadiazole derivatives; 1,2,4-oxadiazole; activity; 1,3,4-oxadiazole

Oxadiazole is a five-membered heterocyclic compound containing two nitrogen atoms and one oxygen atom. The 1,3,4-oxadiazole and 1,2,4-oxadiazole have favourable physical, chemical, and pharmacokinetic properties, which significantly increase their pharmacological activity via hydrogen bond interacti...