Infection risk among adults with down syndrome: a two group series of 101 patients in a tertiary center

• Published in: Orphanet journal of rare diseases Vol. 14; no. 1; pp. 15 - 6
• Main Authors: Guffroy, Aurélien, Dieudonné, Yannick, Uring-Lambert, Beatrice, Goetz, Joelle, Alembik, Yves, Korganow, Anne-Sophie
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.01.2019; BioMed Central; BMC
• Subjects: Adolescent; Adult; Adults; Age; Aged; Analysis; Cancer; Child health; Children; Chromosome Aberrations; Clinical trials; Congenital diseases; Degeneration; Dementia; Dementia disorders; Down syndrome; Down Syndrome - genetics; Down Syndrome - immunology; Down Syndrome - metabolism; Down's syndrome; Elderly patients; Epilepsy; Female; Hospitalization; Hospitals; Humans; Hypothyroidism; Immune system; Immunodeficiency; Infection; Infectious risk; Letter to the Editor; Lymphocytes; Lymphocytopenia; Lymphopenia; Lymphopenia - genetics; Lymphopenia - immunology; Lymphopenia - metabolism; Male; Malignancy; Medical research; Memory; Middle Aged; Mortality; Multivariate analysis; Neurological impairment; Rare diseases; Recurrence (Disease); Retrospective Studies; Risk factors; Streptococcus infections; Tetanus; Thyroid hormones; Young Adult; Neurological impairment; Adult; Down syndrome; Infectious risk; Immunodeficiency

Down syndrome (DS) is the most common form of viable chromosomal abnormality. DS is associated with recurrent infections, auto-immunity and malignancies in children. Little is known about immunity and infections in DS at adulthood. We studied two separate group of adults (> 18 years old) with DS...