Impact of transmission dynamics on the cost-effectiveness of rotavirus vaccination

• Published in: Vaccine Vol. 27; no. 30; pp. 4025 - 4030
• Main Authors: Shim, Eunha, Galvani, Alison P.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 19.06.2009; Elsevier; Elsevier Limited
• Subjects: Allergy and Immunology; Applied microbiology; Biological and medical sciences; Child, Preschool; Children & youth; Cost-Benefit Analysis; Cost-effectiveness; Diarrhea; Emergency medical services; Fundamental and applied biological sciences. Psychology; Herd immunity; Hospitalization; Hospitals; Humans; Incidence; Infant; Microbiology; Miscellaneous; Rotavirus; Rotavirus Infections - economics; Rotavirus Infections - mortality; Rotavirus Infections - prevention & control; Rotavirus Infections - transmission; Rotavirus Vaccines - administration & dosage; Rotavirus Vaccines - economics; Rotavirus Vaccines - immunology; United States; Vaccination; Vaccination - economics; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - economics; Vaccines, Attenuated - immunology; Virology; United States; United States > US; Rotavirus; Cost-effectiveness; Vaccination; Virus; Transmission; Reoviridae; Cost efficiency analysis
• ISSN: 0264-410X; 1873-2518; 1873-2518
• DOI: 10.1016/j.vaccine.2009.04.030

The objective of this study is to estimate the cost-effectiveness of mass vaccination of US infants with the recently available rotavirus vaccine, RotaTeq. We developed a dynamic transmission model of rotavirus to incorporate herd immunity into cost-effectiveness analysis. Our study indicates that a rotavirus vaccination program would prevent about 90% of rotavirus incidence, mortality, hospitalization and emergency department visits annually. We conclude that a universal rotavirus vaccine program in the US would cost $77.30 per case averted from the health care and give a net saving of $80.75 per case averted from the societal perspectives, respectively. The cost per QALY gained was found to be $104,610 when we considered child with one caregiver, making the rotavirus vaccination program a cost-effective intervention.