Mechanisms of Hepatitis B Virus Persistence

• Published in: Trends in microbiology (Regular ed.) Vol. 26; no. 1; pp. 33 - 42
• Main Authors: Tsai, Kuen-Nan, Kuo, Cheng-Fu, Ou, Jing-Hsiung James
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2018; Elsevier Science Ltd
• Subjects: age and maternal effects; Age Factors; antigens; Child; Children; chronic hepatitis B; Chronic infection; Disease transmission; Gastrointestinal Microbiome - immunology; HBV e antigen; Hepatitis; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B virus - genetics; Hepatitis B virus - immunology; Hepatitis B virus - pathogenicity; Hepatitis B virus - physiology; Hepatitis B, Chronic - therapy; Host-Pathogen Interactions - immunology; Humans; Immune system; Immunity; Immunity, Innate; Infectious Disease Transmission, Vertical; Innate immunity; interferon immune responses; Intestinal microflora; intestinal microorganisms; Life Cycle Stages; Maternal Inheritance - immunology; Medical treatment; Microbiota; Offspring; people; vertical transmission; Viral infections; Viral Load; Viruses; chronic hepatitis B; vertical transmission; HBV e antigen; age and maternal effects; interferon immune responses

Hepatitis B virus (HBV) chronically infects 250 million people worldwide, resulting in nearly one million deaths annually. Studies in recent years have significantly improved our knowledge on the mechanisms of HBV persistence. HBV uses multiple pathways to harness host innate immunity to enhance its...