Mechanisms of Hepatitis B Virus Persistence

• Published in: Trends in microbiology (Regular ed.) Vol. 26; no. 1; pp. 33 - 42
• Main Authors: Tsai, Kuen-Nan, Kuo, Cheng-Fu, Ou, Jing-Hsiung James
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2018; Elsevier Science Ltd
• Subjects: age and maternal effects; Age Factors; antigens; Child; Children; chronic hepatitis B; Chronic infection; Disease transmission; Gastrointestinal Microbiome - immunology; HBV e antigen; Hepatitis; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B virus - genetics; Hepatitis B virus - immunology; Hepatitis B virus - pathogenicity; Hepatitis B virus - physiology; Hepatitis B, Chronic - therapy; Host-Pathogen Interactions - immunology; Humans; Immune system; Immunity; Immunity, Innate; Infectious Disease Transmission, Vertical; Innate immunity; interferon immune responses; Intestinal microflora; intestinal microorganisms; Life Cycle Stages; Maternal Inheritance - immunology; Medical treatment; Microbiota; Offspring; people; vertical transmission; Viral infections; Viral Load; Viruses; chronic hepatitis B; vertical transmission; HBV e antigen; age and maternal effects; interferon immune responses
• ISSN: 0966-842X; 1878-4380; 1878-4380
• DOI: 10.1016/j.tim.2017.07.006

Hepatitis B virus (HBV) chronically infects 250 million people worldwide, resulting in nearly one million deaths annually. Studies in recent years have significantly improved our knowledge on the mechanisms of HBV persistence. HBV uses multiple pathways to harness host innate immunity to enhance its replication. It can also take advantage of the developing immune system and the not-yet-stabilized gut microbiota of young children to facilitate its persistence, and use maternal viral e antigen to educate immunity of the offspring to support its persistence after vertical transmission. The knowledge gained from these recent studies paves the way for the development of new therapies for the treatment of chronic HBV infection, which has so far been very challenging. HBV frequently causes chronic infection after vertical transmission but mostly self-limited acute infection after horizontal transmission. HBV harnesses type I interferon immune response to enhance its own replication. HBV persistence is affected by the age of infection, size of viral inoculum, and gut microbiota. Maternal HBeAg can train Kupffer cells of the offspring, likely in utero, to suppress HBV-specific CD8+ T cells in the presence of HBeAg after birth.