A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma

• Published in: Nature genetics Vol. 42; no. 9; pp. 764 - 767
• Main Authors: Abnet, Christian C, Freedman, Neal D, Hu, Nan, Wang, Zhaoming, Yu, Kai, Shu, Xiao-Ou, Yuan, Jian-Min, Zheng, Wei, Dawsey, Sanford M, Dong, Linda M, Lee, Maxwell P, Ding, Ti, Qiao, You-Lin, Gao, Yu-Tang, Koh, Woon-Puay, Xiang, Yong-Bing, Tang, Ze-Zhong, Fan, Jin-Hu, Wang, Chaoyu, Wheeler, William, Gail, Mitchell H, Yeager, Meredith, Yuenger, Jeff, Hutchinson, Amy, Jacobs, Kevin B, Giffen, Carol A, Burdett, Laurie, Fraumeni, Joseph F, Tucker, Margaret A, Chow, Wong-Ho, Goldstein, Alisa M, Chanock, Stephen J, Taylor, Philip R
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.09.2010; Nature Publishing Group
• Subjects: 631/208/727/2000; 631/67/1504/1477; 631/67/1504/1829; Adenocarcinoma - ethnology; Adenocarcinoma - genetics; Agriculture; Analysis; Animal Genetics and Genomics; Asian People - genetics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Carcinoma, Squamous Cell - ethnology; Carcinoma, Squamous Cell - genetics; Case-Control Studies; Chromosomes, Human, Pair 10; Classical genetics, quantitative genetics, hybrids; Diagnosis; Disease susceptibility; Esophageal cancer; Esophageal Neoplasms - ethnology; Esophageal Neoplasms - genetics; Esophagus; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology. Liver. Pancreas. Abdomen; Gene Frequency; Gene Function; Genetic aspects; Genetic Loci; Genetic Predisposition to Disease - genetics; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Human Genetics; Humans; letter; Linkage Disequilibrium; Male; Medical sciences; Methods, theories and miscellaneous; Phosphoinositide Phospholipase C - genetics; Risk factors; Stomach cancer; Stomach Neoplasms - ethnology; Stomach Neoplasms - genetics; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; China; Genetic mapping; Sensitivity; Susceptibility locus; Esophageal disease; Esophagus squamous cell carcinoma; Digestive diseases; Malignant tumor; Stomach adenocarcinoma; Stomach cancer; Cancer; Gastric disease

Christian Abnet and colleagues report genome-wide association studies for gastric adenocarcinoma and esophageal squamous cell carcinoma in a Chinese population. They identified a new shared risk locus in the PLCE1 gene at 10q23. We conducted a genome-wide association study of gastric cancer and esop...