Colistin and its role in the Era of antibiotic resistance: an extended review (2000-2019)

• Published in: Emerging microbes & infections Vol. 9; no. 1; pp. 868 - 885
• Main Authors: El-Sayed Ahmed, Mohamed Abd El-Gawad, Zhong, Lan-Lan, Shen, Cong, Yang, Yongqiang, Doi, Yohei, Tian, Guo-Bao
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2020; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibiotics; Colistin; Colistin - pharmacology; Colistin - therapeutic use; Drug resistance; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria - drug effects; Gram-Negative Bacteria - pathogenicity; Gram-Negative Bacterial Infections - drug therapy; Gram-Negative Bacterial Infections - microbiology; heteroresistance; Humans; MCR-1; multidrug resistance; Multidrug resistant organisms; Pathogens; Review; two-component systems; multidrug resistance; two-component systems; Colistin; heteroresistance; MCR-1

Increasing antibiotic resistance in multidrug-resistant (MDR) Gram-negative bacteria (MDR-GNB) presents significant health problems worldwide, since the vital available and effective antibiotics, including; broad-spectrum penicillins, fluoroquinolones, aminoglycosides, and β-lactams, such as; carbap...