Clinical and genetic factors associated with increased risk of severe liver toxicity in a monocentric cohort of HIV positive patients receiving nevirapine-based antiretroviral therapy

• Published in: BMC infectious diseases Vol. 18; no. 1; pp. 556 - 8
• Main Authors: Giacomelli, Andrea, Riva, Agostino, Falvella, Felicia Stefania, Oreni, Maria Letizia, Cattaneo, Dario, Cheli, Stefania, Renisi, Giulia, Di Cristo, Valentina, Lupo, Angelica, Clementi, Emilio, Rusconi, Stefano, Galli, Massimo, Ridolfo, Anna Lisa
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 12.11.2018; BioMed Central; BMC
• Subjects: ABCB1; Acquired immune deficiency syndrome; Adult; AIDS; Anti-HIV Agents - administration & dosage; Anti-HIV Agents - adverse effects; Anti-Retroviral Agents - administration & dosage; Anti-Retroviral Agents - adverse effects; Antiretroviral agents; Antiretroviral drugs; Antiretroviral therapy; Chemical and Drug Induced Liver Injury - epidemiology; Chemical and Drug Induced Liver Injury - genetics; Cytochrome; Diagnosis; Drug dosages; Drug therapy; Drug Therapy, Combination - adverse effects; Enzymes; Equilibrium methods; Female; Gene expression; Gene mapping; Gene polymorphism; Genetic factors; Genetic Predisposition to Disease; Genomics; Genotype & phenotype; Genotypes; Genotyping; Hepatitis; Hepatitis C virus; Hepatotoxicity; HIV; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - epidemiology; HIV Infections - genetics; Human immunodeficiency virus; Humans; Immune system; Infectious diseases; Liver; Male; Metabolism; Middle Aged; Minority & ethnic groups; Nevirapine; Nevirapine - administration & dosage; Nevirapine - adverse effects; Patients; Pharmacogenetic; Polymorphism; Population; Regression analysis; Regression models; Retrospective Studies; Risk assessment; Risk Factors; Severity of Illness Index; Single-nucleotide polymorphism; Studies; Toxicity; Pharmacogenetic; ABCB1; Nevirapine; Hepatotoxicity

Nevirapine has been used as antiretroviral agent since early '90. Although nevirapine is not currently recommended in initial anti-HIV regimens, its use remains consistent in a certain number of HIV-1-positive subjects. Thus, our aim was to determine clinical and genetic factors involved in the...