Clinical and genetic factors associated with increased risk of severe liver toxicity in a monocentric cohort of HIV positive patients receiving nevirapine-based antiretroviral therapy - Giacomelli, Andrea; Riva, Agostino; Falvella, Felicia Stefania; Oreni, Maria Letizia; Cattaneo, Dario; Cheli, Stefania; Renisi, Giulia; Di Cristo, Valentina; Lupo, Angelica; Clementi, Emilio; Rusconi, Stefano; Galli, Massimo; et al. (BMC infectious diseases, 2018)
Keywords: ABCB1; Acquired immune deficiency syndrome; Adult; AIDS; Anti-HIV Agents - administration & dosage; Anti-HIV Agents - adverse effects; Anti-Retroviral Agents - administration & dosage; Anti-Retroviral Agents - adverse effects; Antiretroviral agents; Antiretroviral drugs; Antiretroviral therapy; Chemical and Drug Induced Liver Injury - epidemiology; Chemical and Drug Induced Liver Injury - genetics; Cytochrome; Diagnosis; Drug dosages; Drug therapy; Drug Therapy, Combination - adverse effects; Enzymes; Equilibrium methods; Female; Gene expression; Gene mapping; Gene polymorphism; Genetic factors; Genetic Predisposition to Disease; Genomics; Genotype & phenotype; Genotypes; Genotyping; Hepatitis; Hepatitis C virus; Hepatotoxicity; HIV; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - epidemiology; HIV Infections - genetics; Human immunodeficiency virus; Humans; Immune system; Infectious diseases; Liver; Male; Metabolism; Middle Aged; Minority & ethnic groups; Nevirapine; Nevirapine - administration & dosage; Nevirapine - adverse effects; Patients; Pharmacogenetic; Polymorphism; Population; Regression analysis; Regression models; Retrospective Studies; Risk assessment; Risk Factors; Severity of Illness Index; Single-nucleotide polymorphism; Studies; Toxicity; Pharmacogenetic; ABCB1; Nevirapine; Hepatotoxicity