Influence of cigarette smoke on the arginine pathway in asthmatic airways: Increased expression of arginase I

• Published in: Journal of allergy and clinical immunology Vol. 119; no. 2; pp. 391 - 397
• Main Authors: Bergeron, Céline, Boulet, Louis-Philippe, Page, Nathalie, Laviolette, Michel, Zimmermann, Nives, Rothenberg, Marc E., Hamid, Qutayba
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.02.2007; Elsevier; Elsevier Limited
• Subjects: Adolescent; Adult; Allergy and Immunology; Arginase - genetics; Arginase I; Arginine - metabolism; Asthma; Asthma - metabolism; Biological and medical sciences; Bronchi - metabolism; Cell growth; cigarette smoke; Cigarettes; Clinical outcomes; Collagen; Enzymes; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Immunohistochemistry; Immunopathology; iNOS; Male; Medical sciences; Nicotine - pharmacology; Nitric oxide; Nitric Oxide - biosynthesis; Nitric Oxide Synthase Type II - analysis; Nitric Oxide Synthase Type II - genetics; ornithine decarboxylase; Ornithine Decarboxylase - analysis; Ornithine Decarboxylase - genetics; Polyamines; RNA, Messenger - analysis; Rodents; Smoking; Smoking - metabolism; NO; NOS; Arginase I; iNOS; ornithine decarboxylase; asthma; cigarette smoke; ODC; Inducible nitric oxide synthase; Nitric oxide; Nitric oxide synthase; Tobacco smoking; Arginase; Lyases; Respiratory system; Cigarette; Respiratory tract; Immunology; Arginine; Carboxy-lyases; Bronchus disease; Obstructive pulmonary disease; Immunopathology; Lung disease; Respiratory disease; Enzyme; Ornithine decarboxylase; Nitric-oxide synthase; Asthma; Carbon-carbon lyases; Aminoacid; Hydrolases; Oxidoreductases

Up to 30% of asthmatic subjects are smokers, and smoking might be an important contributor to asthma pathology. Inducible nitric oxide synthase (iNOS), ornithine decarboxylase (ODC), and arginase I are involved in the arginine pathway. We have shown that arginase I and iNOS are upregulated in asthma...