Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients

• Published in: Emerging microbes & infections Vol. 9; no. 1; pp. 761 - 770
• Main Authors: Xiong, Yong, Liu, Yuan, Cao, Liu, Wang, Dehe, Guo, Ming, Jiang, Ao, Guo, Dong, Hu, Wenjia, Yang, Jiayi, Tang, Zhidong, Wu, Honglong, Lin, Yongquan, Zhang, Meiyuan, Zhang, Qi, Shi, Mang, Liu, Yingle, Zhou, Yu, Lan, Ke, Chen, Yu
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2020; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Apoptosis; Betacoronavirus; Bronchoalveolar Lavage Fluid; Chemokines - analysis; Coronavirus Infections - blood; Coronavirus Infections - genetics; Coronavirus Infections - immunology; Coronaviruses; COVID-19; cytokine; Cytokines; Cytokines - analysis; Humans; inflammation; Lavage; Leukocytes, Mononuclear; Lymphopenia; Pandemics; Pneumonia, Viral - blood; Pneumonia, Viral - genetics; Pneumonia, Viral - immunology; RNA-Seq; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Signal Transduction; Transcriptome; transcriptome profiling; Tumor Suppressor Protein p53; COVID-19; cytokine; transcriptome profiling; inflammation; lymphopenia

Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of hos...