A novel cuproptosis-related gene model predicts outcomes and treatment responses in pancreatic adenocarcinoma

• Published in: BMC cancer Vol. 23; no. 1; pp. 226 - 17
• Main Authors: Liu, Qixian, Li, Ruiyu, Wu, Huanwen, Liang, Zhiyong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.03.2023; BioMed Central; BMC
• Subjects: Adenocarcinoma; Adenocarcinoma - genetics; Adenocarcinoma - therapy; Analysis; Apoptosis; Biological markers; Biomarkers; Cancer research; Cancer therapies; Care and treatment; Chemotherapy; Copper; Cuproptosis; Datasets; Diagnosis; DNA-Binding Proteins; Gene expression; Genetic aspects; Genomes; Genomics; Humans; Immunohistochemistry; Immunosuppressive agents; Immunotherapy; Lymphocytes; Medical prognosis; Molecular modelling; Mutation rates; Nomograms; p53 Protein; Pancreas; Pancreatic adenocarcinoma; Pancreatic cancer; Pancreatic Neoplasms; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - therapy; Patient outcomes; Patients; Prognosis; Proteins; Regression analysis; Risk groups; Risk model; Transcription Factors; Treatment response; Tumor microenvironment; Tumor proteins; China; Risk model; Prognosis; Tumor microenvironment; Cuproptosis; Immunotherapy; Pancreatic adenocarcinoma; Treatment response

Cuproptosis is recently emerging as a hot spot in cancer research. However, its role in pancreatic adenocarcinoma (PAAD) has not yet been clarified. This study aimed to explore the prognostic and therapeutic implications of cuproptosis-related genes in PAAD. Two hundred thirteen PAAD samples from th...