The immune response of the human brain to abdominal surgery

• Published in: Annals of neurology Vol. 81; no. 4; pp. 572 - 582
• Main Authors: Forsberg, Anton, Cervenka, Simon, Jonsson Fagerlund, Malin, Rasmussen, Lars S., Zetterberg, Henrik, Erlandsson Harris, Helena, Stridh, Pernilla, Christensson, Eva, Granström, Anna, Schening, Anna, Dymmel, Karin, Knave, Nina, Terrando, Niccolò, Maze, Mervyn, Borg, Jacqueline, Varrone, Andrea, Halldin, Christer, Blennow, Kaj, Farde, Lars, Eriksson, Lars I.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2017
• Subjects: Abdomen - surgery; Abdominal surgery; Activation analysis; Aged; Anesthesia; benzodiazepine-receptors; Binding; Biomarkers; Biomarkers - metabolism; Blood; Brain; Brain - diagnostic imaging; Brain - immunology; Brain - metabolism; Brain - physiopathology; Cell activation; cerebrospinal-fluid; Cognitive ability; Cognitive Dysfunction - etiology; Cognitive Dysfunction - physiopathology; Color; Correlation; Down-Regulation; Emission; Follow-Up Studies; Gray Matter - diagnostic imaging; Gray Matter - immunology; Gray Matter - metabolism; Gray Matter - physiopathology; Humans; Imaging; Immune response; Immune system; Immunoreactivity; in-vivo; Inflammation; Inflammatory response; Innate immunity; Lipopolysaccharides; Male; Males; microglial activation; Middle Aged; neurofilament light; Neuroimaging; Neurosciences; Neurosciences & Neurology; Neurovetenskaper; Patients; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; postoperative cognitive dysfunction; Prostate cancer; Prostatectomy; Prostatectomy - adverse effects; protein 18 kda; Signal transduction; Standard deviation; Stimulation; Substantia grisea; Surgery; T cell receptors; Tomography; translocator protein; Tumor necrosis factor; Urological surgery; vivo radioligand binding

Objective Surgery launches a systemic inflammatory reaction that reaches the brain and associates with immune activation and cognitive decline. Although preclinical studies have in part described this systemic‐to‐brain signaling pathway, we lack information on how these changes appear in humans. Thi...