Interleukin‐2‐inducible Killer Activity and Its Regulation by Blood Monocytes from Autologous Lymphocytes of Lung Cancer Patients

• Published in: Cancer science Vol. 82; no. 6; pp. 716 - 723
• Main Authors: Sone, Saburo, Kunishige, Eiji, Fawzy, Farid, Yanagawa, Hiroaki, Nil, Akihiko, Maeda, Ken‐ichi, Atagi, Shinji, Heike, Yuji, Nishioka, Yasuhiko, Mizuno, Kazuhito, Ogura, Takeshi
• Format: Journal Article
• Language: English
• Published: Oxford, UK Wiley 01.06.1991; Blackwell Publishing Ltd; Japanese Cancer Association; John Wiley & Sons, Inc
• Subjects: Adenocarcinoma; Aged; Biological and medical sciences; Blood; Carcinoma, Non-Small-Cell Lung; Carcinoma, Non-Small-Cell Lung - immunology; Carcinoma, Small Cell; Carcinoma, Small Cell - immunology; Cell Line; Cytokines; Cytotoxicity, Immunologic; Female; Humans; Interleukin 2; Interleukin-2 - pharmacology; Killer Cells, Lymphokine-Activated; Killer Cells, Lymphokine-Activated - immunology; Killer Cells, Natural; Killer Cells, Natural - drug effects; Killer Cells, Natural - immunology; Leukocytes (mononuclear); Lung cancer; Lung Neoplasms; Lung Neoplasms - immunology; Lymphocyte; Lymphocytes; Lymphocytes - immunology; Lymphokine-activated killer cells; Male; Medical sciences; Middle Aged; Monocyte; Monocytes; Recombinant Proteins; Recombinant Proteins - pharmacology; Reference Values; Small cell lung carcinoma; Tumors; Human; Regulation(control); Interleukin 2; Monocyte; Pathophysiology; Respiratory disease; Induction; Lung; LAK cell; Malignant tumor; Lymphocyte

The ability of blood lymphocytes of newly diagnosed lung cancer patients to respond to interleukin 2 (IL‐2) to become IL‐2‐activated killer (LAK) cells and its regulation by autologous monocytes were examined. LAK activity was measured by 31Cr release assay. The abilities of lymphocytes among blood...