Regional association of pCASL-MRI with FDG-PET and PiB-PET in people at risk for autosomal dominant Alzheimer's disease
Autosomal dominant Alzheimer's disease (ADAD) is a small subset of Alzheimer's disease that is genetically determined with 100% penetrance. It provides a valuable window into studying the course of pathologic processes that leads to dementia. Arterial spin labeling (ASL) MRI is a potential...
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| Published in | NeuroImage clinical Vol. 17; pp. 751 - 760 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Inc
01.01.2018
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2213-1582 2213-1582 |
| DOI | 10.1016/j.nicl.2017.12.003 |
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| Abstract | Autosomal dominant Alzheimer's disease (ADAD) is a small subset of Alzheimer's disease that is genetically determined with 100% penetrance. It provides a valuable window into studying the course of pathologic processes that leads to dementia. Arterial spin labeling (ASL) MRI is a potential AD imaging marker that non-invasively measures cerebral perfusion. In this study, we investigated the relationship of cerebral blood flow measured by pseudo-continuous ASL (pCASL) MRI with measures of cerebral metabolism (FDG PET) and amyloid deposition (Pittsburgh Compound B (PiB) PET). Thirty-one participants at risk for ADAD (age 39±13years, 19 females) were recruited into this study, and 21 of them received both MRI and FDG and PiB PET scans. Considerable variability was observed in regional correlations between ASL-CBF and FDG across subjects. Both regional hypo-perfusion and hypo-metabolism were associated with amyloid deposition. Cross-sectional analyses of each biomarker as a function of the estimated years to expected dementia diagnosis indicated an inverse relationship of both perfusion and glucose metabolism with amyloid deposition during AD development. These findings indicate that neurovascular dysfunction is associated with amyloid pathology, and also indicate that ASL CBF may serve as a sensitive early biomarker for AD. The direct comparison among the three biomarkers provides complementary information for understanding the pathophysiological process of AD.
•Regional associations of three imaging biomarkers (pCASL-MRI, FDG-PET and PiB-PET) are studied in persons at risk for ADAD.•PiB-PET shows different spatial pattern compared to pCASL-MRI and FDG-PET.•There is considerable variability among regional correlations between pCASL and FDG.•Both regional hypo-perfusion and hypo-metabolism are associated with amyloid deposition. |
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| AbstractList | Autosomal dominant Alzheimer's disease (ADAD) is a small subset of Alzheimer's disease that is genetically determined with 100% penetrance. It provides a valuable window into studying the course of pathologic processes that leads to dementia. Arterial spin labeling (ASL) MRI is a potential AD imaging marker that non-invasively measures cerebral perfusion. In this study, we investigated the relationship of cerebral blood flow measured by pseudo-continuous ASL (pCASL) MRI with measures of cerebral metabolism (FDG PET) and amyloid deposition (Pittsburgh Compound B (PiB) PET). Thirty-one participants at risk for ADAD (age 39 ± 13 years, 19 females) were recruited into this study, and 21 of them received both MRI and FDG and PiB PET scans. Considerable variability was observed in regional correlations between ASL-CBF and FDG across subjects. Both regional hypo-perfusion and hypo-metabolism were associated with amyloid deposition. Cross-sectional analyses of each biomarker as a function of the estimated years to expected dementia diagnosis indicated an inverse relationship of both perfusion and glucose metabolism with amyloid deposition during AD development. These findings indicate that neurovascular dysfunction is associated with amyloid pathology, and also indicate that ASL CBF may serve as a sensitive early biomarker for AD. The direct comparison among the three biomarkers provides complementary information for understanding the pathophysiological process of AD.
•
Regional associations of three imaging biomarkers (pCASL-MRI, FDG-PET and PiB-PET) are studied in persons at risk for ADAD.
•
PiB-PET shows different spatial pattern compared to pCASL-MRI and FDG-PET.
•
There is considerable variability among regional correlations between pCASL and FDG.
•
Both regional hypo-perfusion and hypo-metabolism are associated with amyloid deposition. Autosomal dominant Alzheimer's disease (ADAD) is a small subset of Alzheimer's disease that is genetically determined with 100% penetrance. It provides a valuable window into studying the course of pathologic processes that leads to dementia. Arterial spin labeling (ASL) MRI is a potential AD imaging marker that non-invasively measures cerebral perfusion. In this study, we investigated the relationship of cerebral blood flow measured by pseudo-continuous ASL (pCASL) MRI with measures of cerebral metabolism (FDG PET) and amyloid deposition (Pittsburgh Compound B (PiB) PET). Thirty-one participants at risk for ADAD (age 39 ± 13 years, 19 females) were recruited into this study, and 21 of them received both MRI and FDG and PiB PET scans. Considerable variability was observed in regional correlations between ASL-CBF and FDG across subjects. Both regional hypo-perfusion and hypo-metabolism were associated with amyloid deposition. Cross-sectional analyses of each biomarker as a function of the estimated years to expected dementia diagnosis indicated an inverse relationship of both perfusion and glucose metabolism with amyloid deposition during AD development. These findings indicate that neurovascular dysfunction is associated with amyloid pathology, and also indicate that ASL CBF may serve as a sensitive early biomarker for AD. The direct comparison among the three biomarkers provides complementary information for understanding the pathophysiological process of AD. Autosomal dominant Alzheimer's disease (ADAD) is a small subset of Alzheimer's disease that is genetically determined with 100% penetrance. It provides a valuable window into studying the course of pathologic processes that leads to dementia. Arterial spin labeling (ASL) MRI is a potential AD imaging marker that non-invasively measures cerebral perfusion. In this study, we investigated the relationship of cerebral blood flow measured by pseudo-continuous ASL (pCASL) MRI with measures of cerebral metabolism (FDG PET) and amyloid deposition (Pittsburgh Compound B (PiB) PET). Thirty-one participants at risk for ADAD (age 39±13years, 19 females) were recruited into this study, and 21 of them received both MRI and FDG and PiB PET scans. Considerable variability was observed in regional correlations between ASL-CBF and FDG across subjects. Both regional hypo-perfusion and hypo-metabolism were associated with amyloid deposition. Cross-sectional analyses of each biomarker as a function of the estimated years to expected dementia diagnosis indicated an inverse relationship of both perfusion and glucose metabolism with amyloid deposition during AD development. These findings indicate that neurovascular dysfunction is associated with amyloid pathology, and also indicate that ASL CBF may serve as a sensitive early biomarker for AD. The direct comparison among the three biomarkers provides complementary information for understanding the pathophysiological process of AD. •Regional associations of three imaging biomarkers (pCASL-MRI, FDG-PET and PiB-PET) are studied in persons at risk for ADAD.•PiB-PET shows different spatial pattern compared to pCASL-MRI and FDG-PET.•There is considerable variability among regional correlations between pCASL and FDG.•Both regional hypo-perfusion and hypo-metabolism are associated with amyloid deposition. Autosomal dominant Alzheimer's disease (ADAD) is a small subset of Alzheimer's disease that is genetically determined with 100% penetrance. It provides a valuable window into studying the course of pathologic processes that leads to dementia. Arterial spin labeling (ASL) MRI is a potential AD imaging marker that non-invasively measures cerebral perfusion. In this study, we investigated the relationship of cerebral blood flow measured by pseudo-continuous ASL (pCASL) MRI with measures of cerebral metabolism (FDG PET) and amyloid deposition (Pittsburgh Compound B (PiB) PET). Thirty-one participants at risk for ADAD (age 39±13years, 19 females) were recruited into this study, and 21 of them received both MRI and FDG and PiB PET scans. Considerable variability was observed in regional correlations between ASL-CBF and FDG across subjects. Both regional hypo-perfusion and hypo-metabolism were associated with amyloid deposition. Cross-sectional analyses of each biomarker as a function of the estimated years to expected dementia diagnosis indicated an inverse relationship of both perfusion and glucose metabolism with amyloid deposition during AD development. These findings indicate that neurovascular dysfunction is associated with amyloid pathology, and also indicate that ASL CBF may serve as a sensitive early biomarker for AD. The direct comparison among the three biomarkers provides complementary information for understanding the pathophysiological process of AD. Keywords: Autosomal dominant Alzheimer's disease, Arterial spin labeling, MRI, FDG pet, PiB PET, Cerebral perfusion, Glucose metabolism, Amyloid deposition AbstractAutosomal dominant Alzheimer's disease (ADAD) is a small subset of Alzheimer's disease that is genetically determined with 100% penetrance. It provides a valuable window into studying the course of pathologic processes that leads to dementia. Arterial spin labeling (ASL) MRI is a potential AD imaging marker that non-invasively measures cerebral perfusion. In this study, we investigated the relationship of cerebral blood flow measured by pseudo-continuous ASL (pCASL) MRI with measures of cerebral metabolism (FDG PET) and amyloid deposition (Pittsburgh Compound B (PiB) PET). Thirty-one participants at risk for ADAD (age 39 ± 13 years, 19 females) were recruited into this study, and 21 of them received both MRI and FDG and PiB PET scans. Considerable variability was observed in regional correlations between ASL-CBF and FDG across subjects. Both regional hypo-perfusion and hypo-metabolism were associated with amyloid deposition. Cross-sectional analyses of each biomarker as a function of the estimated years to expected dementia diagnosis indicated an inverse relationship of both perfusion and glucose metabolism with amyloid deposition during AD development. These findings indicate that neurovascular dysfunction is associated with amyloid pathology, and also indicate that ASL CBF may serve as a sensitive early biomarker for AD. The direct comparison among the three biomarkers provides complementary information for understanding the pathophysiological process of AD. Autosomal dominant Alzheimer's disease (ADAD) is a small subset of Alzheimer's disease that is genetically determined with 100% penetrance. It provides a valuable window into studying the course of pathologic processes that leads to dementia. Arterial spin labeling (ASL) MRI is a potential AD imaging marker that non-invasively measures cerebral perfusion. In this study, we investigated the relationship of cerebral blood flow measured by pseudo-continuous ASL (pCASL) MRI with measures of cerebral metabolism (FDG PET) and amyloid deposition (Pittsburgh Compound B (PiB) PET). Thirty-one participants at risk for ADAD (age 39 ± 13 years, 19 females) were recruited into this study, and 21 of them received both MRI and FDG and PiB PET scans. Considerable variability was observed in regional correlations between ASL-CBF and FDG across subjects. Both regional hypo-perfusion and hypo-metabolism were associated with amyloid deposition. Cross-sectional analyses of each biomarker as a function of the estimated years to expected dementia diagnosis indicated an inverse relationship of both perfusion and glucose metabolism with amyloid deposition during AD development. These findings indicate that neurovascular dysfunction is associated with amyloid pathology, and also indicate that ASL CBF may serve as a sensitive early biomarker for AD. The direct comparison among the three biomarkers provides complementary information for understanding the pathophysiological process of AD.Autosomal dominant Alzheimer's disease (ADAD) is a small subset of Alzheimer's disease that is genetically determined with 100% penetrance. It provides a valuable window into studying the course of pathologic processes that leads to dementia. Arterial spin labeling (ASL) MRI is a potential AD imaging marker that non-invasively measures cerebral perfusion. In this study, we investigated the relationship of cerebral blood flow measured by pseudo-continuous ASL (pCASL) MRI with measures of cerebral metabolism (FDG PET) and amyloid deposition (Pittsburgh Compound B (PiB) PET). Thirty-one participants at risk for ADAD (age 39 ± 13 years, 19 females) were recruited into this study, and 21 of them received both MRI and FDG and PiB PET scans. Considerable variability was observed in regional correlations between ASL-CBF and FDG across subjects. Both regional hypo-perfusion and hypo-metabolism were associated with amyloid deposition. Cross-sectional analyses of each biomarker as a function of the estimated years to expected dementia diagnosis indicated an inverse relationship of both perfusion and glucose metabolism with amyloid deposition during AD development. These findings indicate that neurovascular dysfunction is associated with amyloid pathology, and also indicate that ASL CBF may serve as a sensitive early biomarker for AD. The direct comparison among the three biomarkers provides complementary information for understanding the pathophysiological process of AD. |
| Author | Jann, Kay Huang, Sung-Cheng Mack, Wendy J. Coppola, Giovanni Wang, Danny J.J. Ringman, John M. Yan, Lirong Wong, Koon-Pong Liu, Collin Y. |
| AuthorAffiliation | a Laboratory of FMRI Technology (LOFT), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA b Department of Neurology, University of Southern California, Los Angeles, CA, USA f Semel Institute of Psychiatry and Biobehavioral Sciences UCLA, USA d Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA c Alzheimer's Disease Research Center, University of Southern California, Los Angeles, CA, USA e Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA |
| AuthorAffiliation_xml | – name: b Department of Neurology, University of Southern California, Los Angeles, CA, USA – name: e Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA – name: d Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA – name: c Alzheimer's Disease Research Center, University of Southern California, Los Angeles, CA, USA – name: a Laboratory of FMRI Technology (LOFT), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA – name: f Semel Institute of Psychiatry and Biobehavioral Sciences UCLA, USA |
| Author_xml | – sequence: 1 givenname: Lirong surname: Yan fullname: Yan, Lirong email: lyan@ini.usc.edu organization: Laboratory of FMRI Technology (LOFT), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA – sequence: 2 givenname: Collin Y. surname: Liu fullname: Liu, Collin Y. organization: Department of Neurology, University of Southern California, Los Angeles, CA, USA – sequence: 3 givenname: Koon-Pong surname: Wong fullname: Wong, Koon-Pong organization: Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA – sequence: 4 givenname: Sung-Cheng surname: Huang fullname: Huang, Sung-Cheng organization: Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA – sequence: 5 givenname: Wendy J. surname: Mack fullname: Mack, Wendy J. organization: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA – sequence: 6 givenname: Kay surname: Jann fullname: Jann, Kay organization: Laboratory of FMRI Technology (LOFT), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA – sequence: 7 givenname: Giovanni surname: Coppola fullname: Coppola, Giovanni organization: Semel Institute of Psychiatry and Biobehavioral Sciences UCLA, USA – sequence: 8 givenname: John M. surname: Ringman fullname: Ringman, John M. organization: Department of Neurology, University of Southern California, Los Angeles, CA, USA – sequence: 9 givenname: Danny J.J. surname: Wang fullname: Wang, Danny J.J. organization: Laboratory of FMRI Technology (LOFT), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA |
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| Keywords | Glucose metabolism MRI Cerebral perfusion Arterial spin labeling PiB PET Amyloid deposition Autosomal dominant Alzheimer's disease FDG pet |
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| Snippet | Autosomal dominant Alzheimer's disease (ADAD) is a small subset of Alzheimer's disease that is genetically determined with 100% penetrance. It provides a... AbstractAutosomal dominant Alzheimer's disease (ADAD) is a small subset of Alzheimer's disease that is genetically determined with 100% penetrance. It provides... |
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| SubjectTerms | Adult Alzheimer Disease - diagnostic imaging Alzheimer Disease - genetics Amyloid beta-Protein Precursor - genetics Amyloid deposition Aniline Compounds - metabolism Arterial spin labeling Autosomal dominant Alzheimer's disease Brain - diagnostic imaging Cerebral perfusion Cerebrovascular Circulation - physiology Cross-Sectional Studies FDG pet Female Fluorodeoxyglucose F18 - metabolism Glucose metabolism Humans Magnetic Resonance Imaging Male Middle Aged MRI PiB PET Positron-Emission Tomography - methods Presenilin-1 - genetics Presenilin-2 Radiology Regular Spin Labels Thiazoles - metabolism Young Adult |
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| Title | Regional association of pCASL-MRI with FDG-PET and PiB-PET in people at risk for autosomal dominant Alzheimer's disease |
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