Role of caspofungin in restoring the impaired phagocyte-dependent innate immunity towards Candida albicans in chronic haemodialysis patients
Phagocyte-dependent cellular immunity in chronic kidney disease patients undergoing haemodialysis treatment is frequently impaired owing to the uraemic state, resulting in an intrinsic susceptibility to developing invasive fungal infections with high mortality rates. Since synergism between phagocyt...
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| Published in | International journal of antimicrobial agents Vol. 39; no. 1; pp. 73 - 76 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier B.V
01.01.2012
Elsevier |
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| Abstract | Phagocyte-dependent cellular immunity in chronic kidney disease patients undergoing haemodialysis treatment is frequently impaired owing to the uraemic state, resulting in an intrinsic susceptibility to developing invasive fungal infections with high mortality rates. Since synergism between phagocytic cells and antifungal drugs may be crucial for successful therapy, the aim of this study was to evaluate the effects exerted by caspofungin (CAS) on the functional activities of polymorphonuclear cells (PMNs) in haemodialysed patients (HDs) towards
Candida albicans compared with those of PMNs from healthy subjects (HSs). PMNs were separated from venous blood samples of 66 HDs and 30 HSs (as controls), and measurement of phagocytic and intracellular fungicidal activities of HD-PMNs and HS-PMNs was performed in the presence of CAS at the minimum inhibitory concentration (MIC) and at sub-MICs. CAS-free controls were also included. In the drug-free test condition, no significant difference between the phagocytic activity of HD-PMNs and HS-PMNs was detected. In contrast, a progressive decline in the intracellular killing activity of HD-PMNs against proliferating yeasts was observed. CAS at MIC and sub-MIC levels was able to improve significantly the intracellular fungicidal activity of HD-PMNs against
C. albicans, restoring their functionality. These findings provide evidence that CAS exerts a synergistic effect on HD-PMNs against
C. albicans, being able to strength the depressed intracellular killing activity. These results corroborate the use of CAS as an effective therapeutic option for the treatment of invasive fungal infections in HDs, in whom even a marginal influence of antifungal drugs on host response may have a relevant effect. |
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| AbstractList | Phagocyte-dependent cellular immunity in chronic kidney disease patients undergoing haemodialysis treatment is frequently impaired owing to the uraemic state, resulting in an intrinsic susceptibility to developing invasive fungal infections with high mortality rates. Since synergism between phagocytic cells and antifungal drugs may be crucial for successful therapy, the aim of this study was to evaluate the effects exerted by caspofungin (CAS) on the functional activities of polymorphonuclear cells (PMNs) in haemodialysed patients (HDs) towards Candida albicans compared with those of PMNs from healthy subjects (HSs). PMNs were separated from venous blood samples of 66 HDs and 30 HSs (as controls), and measurement of phagocytic and intracellular fungicidal activities of HD-PMNs and HS-PMNs was performed in the presence of CAS at the minimum inhibitory concentration (MIC) and at sub-MICs. CAS-free controls were also included. In the drug-free test condition, no significant difference between the phagocytic activity of HD-PMNs and HS-PMNs was detected. In contrast, a progressive decline in the intracellular killing activity of HD-PMNs against proliferating yeasts was observed. CAS at MIC and sub-MIC levels was able to improve significantly the intracellular fungicidal activity of HD-PMNs against C. albicans, restoring their functionality. These findings provide evidence that CAS exerts a synergistic effect on HD-PMNs against C. albicans, being able to strength the depressed intracellular killing activity. These results corroborate the use of CAS as an effective therapeutic option for the treatment of invasive fungal infections in HDs, in whom even a marginal influence of antifungal drugs on host response may have a relevant effect. Phagocyte-dependent cellular immunity in chronic kidney disease patients undergoing haemodialysis treatment is frequently impaired owing to the uraemic state, resulting in an intrinsic susceptibility to developing invasive fungal infections with high mortality rates. Since synergism between phagocytic cells and antifungal drugs may be crucial for successful therapy, the aim of this study was to evaluate the effects exerted by caspofungin (CAS) on the functional activities of polymorphonuclear cells (PMNs) in haemodialysed patients (HDs) towards Candida albicans compared with those of PMNs from healthy subjects (HSs). PMNs were separated from venous blood samples of 66 HDs and 30 HSs (as controls), and measurement of phagocytic and intracellular fungicidal activities of HD-PMNs and HS-PMNs was performed in the presence of CAS at the minimum inhibitory concentration (MIC) and at sub-MICs. CAS-free controls were also included. In the drug-free test condition, no significant difference between the phagocytic activity of HD-PMNs and HS-PMNs was detected. In contrast, a progressive decline in the intracellular killing activity of HD-PMNs against proliferating yeasts was observed. CAS at MIC and sub-MIC levels was able to improve significantly the intracellular fungicidal activity of HD-PMNs against C. albicans, restoring their functionality. These findings provide evidence that CAS exerts a synergistic effect on HD-PMNs against C. albicans, being able to strength the depressed intracellular killing activity. These results corroborate the use of CAS as an effective therapeutic option for the treatment of invasive fungal infections in HDs, in whom even a marginal influence of antifungal drugs on host response may have a relevant effect. Phagocyte-dependent cellular immunity in chronic kidney disease patients undergoing haemodialysis treatment is frequently impaired owing to the uraemic state, resulting in an intrinsic susceptibility to developing invasive fungal infections with high mortality rates. Since synergism between phagocytic cells and antifungal drugs may be crucial for successful therapy, the aim of this study was to evaluate the effects exerted by caspofungin (CAS) on the functional activities of polymorphonuclear cells (PMNs) in haemodialysed patients (HDs) towards Candida albicans compared with those of PMNs from healthy subjects (HSs). PMNs were separated from venous blood samples of 66 HDs and 30 HSs (as controls), and measurement of phagocytic and intracellular fungicidal activities of HD-PMNs and HS-PMNs was performed in the presence of CAS at the minimum inhibitory concentration (MIC) and at sub-MICs. CAS-free controls were also included. In the drug-free test condition, no significant difference between the phagocytic activity of HD-PMNs and HS-PMNs was detected. In contrast, a progressive decline in the intracellular killing activity of HD-PMNs against proliferating yeasts was observed. CAS at MIC and sub-MIC levels was able to improve significantly the intracellular fungicidal activity of HD-PMNs against C. albicans, restoring their functionality. These findings provide evidence that CAS exerts a synergistic effect on HD-PMNs against C. albicans, being able to strength the depressed intracellular killing activity. These results corroborate the use of CAS as an effective therapeutic option for the treatment of invasive fungal infections in HDs, in whom even a marginal influence of antifungal drugs on host response may have a relevant effect.Phagocyte-dependent cellular immunity in chronic kidney disease patients undergoing haemodialysis treatment is frequently impaired owing to the uraemic state, resulting in an intrinsic susceptibility to developing invasive fungal infections with high mortality rates. Since synergism between phagocytic cells and antifungal drugs may be crucial for successful therapy, the aim of this study was to evaluate the effects exerted by caspofungin (CAS) on the functional activities of polymorphonuclear cells (PMNs) in haemodialysed patients (HDs) towards Candida albicans compared with those of PMNs from healthy subjects (HSs). PMNs were separated from venous blood samples of 66 HDs and 30 HSs (as controls), and measurement of phagocytic and intracellular fungicidal activities of HD-PMNs and HS-PMNs was performed in the presence of CAS at the minimum inhibitory concentration (MIC) and at sub-MICs. CAS-free controls were also included. In the drug-free test condition, no significant difference between the phagocytic activity of HD-PMNs and HS-PMNs was detected. In contrast, a progressive decline in the intracellular killing activity of HD-PMNs against proliferating yeasts was observed. CAS at MIC and sub-MIC levels was able to improve significantly the intracellular fungicidal activity of HD-PMNs against C. albicans, restoring their functionality. These findings provide evidence that CAS exerts a synergistic effect on HD-PMNs against C. albicans, being able to strength the depressed intracellular killing activity. These results corroborate the use of CAS as an effective therapeutic option for the treatment of invasive fungal infections in HDs, in whom even a marginal influence of antifungal drugs on host response may have a relevant effect. Abstract Phagocyte-dependent cellular immunity in chronic kidney disease patients undergoing haemodialysis treatment is frequently impaired owing to the uraemic state, resulting in an intrinsic susceptibility to developing invasive fungal infections with high mortality rates. Since synergism between phagocytic cells and antifungal drugs may be crucial for successful therapy, the aim of this study was to evaluate the effects exerted by caspofungin (CAS) on the functional activities of polymorphonuclear cells (PMNs) in haemodialysed patients (HDs) towards Candida albicans compared with those of PMNs from healthy subjects (HSs). PMNs were separated from venous blood samples of 66 HDs and 30 HSs (as controls), and measurement of phagocytic and intracellular fungicidal activities of HD-PMNs and HS-PMNs was performed in the presence of CAS at the minimum inhibitory concentration (MIC) and at sub-MICs. CAS-free controls were also included. In the drug-free test condition, no significant difference between the phagocytic activity of HD-PMNs and HS-PMNs was detected. In contrast, a progressive decline in the intracellular killing activity of HD-PMNs against proliferating yeasts was observed. CAS at MIC and sub-MIC levels was able to improve significantly the intracellular fungicidal activity of HD-PMNs against C. albicans , restoring their functionality. These findings provide evidence that CAS exerts a synergistic effect on HD-PMNs against C. albicans , being able to strength the depressed intracellular killing activity. These results corroborate the use of CAS as an effective therapeutic option for the treatment of invasive fungal infections in HDs, in whom even a marginal influence of antifungal drugs on host response may have a relevant effect. |
| Author | Garneri, Giuseppe Roana, Janira Merlino, Chiara Patti, Rosaria Tullio, Vivian Cuffini, Anna Maria Giacchino, Franca Allizond, Valeria Scalas, Daniela Banche, Giuliana Mandras, Narcisa |
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| Keywords | Intracellular killing Candida albicans Haemodialysis patients Polymorphonuclear cells PMNs Caspofungin Phagocytosis Human Yeast Hemodialysis Granulocyte Natural immunity Patient In vitro Echinocandine derivatives Fungi Antifungal agent Chronic Fungi Imperfecti Intracellular Neutrophil Cell Phagocyte |
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| References | Frank, Greiner, Engels, Daschner (bib0045) 2004; 23 Roilides, Walsh, Rubin, Venzon, Pizzo (bib0115) 1990; 34 Richardson, Scott, Shankland (bib0035) 1992; 11 Tullio, Cuffini, Giacchino, Mandras, Roana, Comune (bib0120) 2003; 15 Cuffini, Tullio, Giacchino, Mandras, Scalas, Belardi (bib0095) 2001; 37 Clinical and Laboratory Standards Institute. Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard. 3rd ed. M27-A3. Wayne, PA: CLSI; 2008. Chiller, Farrokhshad, Brummer, Stevens (bib0040) 2001; 39 Mahajan, Kalra, Asit, Ahuja, Kalra (bib0025) 2005; 27 Tullio, Cuffini, Banche, Mandras, Allizond, Roana (bib0100) 2008; 21 Banche, Tullio, Allizond, Mandras, Roana, Scalas (bib0090) 2010; 36 Giacchino, Allizond, Tullio, Scalas, Roana, Garneri (bib0125) 2010 Hauser, Stinghen, Kato, Bucharles, Aita, Yuzawa (bib0030) 2008; 28 Banche, Allizond, Giacchino, Mandras, Roana, Bonello (bib0085) 2006; 21 Tullio, Mandras, Scalas, Allizond, Banche, Roana (bib0075) 2010; 54 Ben-Ami, Lewis, Kontoyiannis (bib0070) 2008; 47 Pyrgos, Ratanavanich, Donegan, Veis, Walsh, Shoham (bib0010) 2009; 47 Cohen, Haag-Weber, Hörl (bib0015) 1997; 62 Brummer, Chauhan, Stevens (bib0060) 1999; 43 Cuffini, Tullio, Banche, Allizond, Mandras, Roana (bib0105) 2009; 22 Girndt, Sester, Sester, Kaul, Kohler (bib0020) 2001; 78 Sardenberg, Suassuna, Andreoli, Watanabe, Dalboni, Manfredi (bib0110) 2006; 21 Lamaris, Lewis, Chamilos, May, Safdar, Walsh (bib0065) 2008; 198 Groll, Tragiannidis (bib0055) 2009; 46 Choi, Brummer, Stevens (bib0050) 2004; 6 Gandhi, Bahadur, Dodeja, Aggrwal, Thamba, Mali (bib0005) 2005; 51 Giacchino (10.1016/j.ijantimicag.2011.09.015_bib0125) 2010 Gandhi (10.1016/j.ijantimicag.2011.09.015_bib0005) 2005; 51 Brummer (10.1016/j.ijantimicag.2011.09.015_bib0060) 1999; 43 Pyrgos (10.1016/j.ijantimicag.2011.09.015_bib0010) 2009; 47 Ben-Ami (10.1016/j.ijantimicag.2011.09.015_bib0070) 2008; 47 Cuffini (10.1016/j.ijantimicag.2011.09.015_bib0105) 2009; 22 Chiller (10.1016/j.ijantimicag.2011.09.015_bib0040) 2001; 39 Roilides (10.1016/j.ijantimicag.2011.09.015_bib0115) 1990; 34 Tullio (10.1016/j.ijantimicag.2011.09.015_bib0075) 2010; 54 Girndt (10.1016/j.ijantimicag.2011.09.015_bib0020) 2001; 78 Banche (10.1016/j.ijantimicag.2011.09.015_bib0085) 2006; 21 Mahajan (10.1016/j.ijantimicag.2011.09.015_bib0025) 2005; 27 Hauser (10.1016/j.ijantimicag.2011.09.015_bib0030) 2008; 28 Frank (10.1016/j.ijantimicag.2011.09.015_bib0045) 2004; 23 Choi (10.1016/j.ijantimicag.2011.09.015_bib0050) 2004; 6 Groll (10.1016/j.ijantimicag.2011.09.015_bib0055) 2009; 46 Sardenberg (10.1016/j.ijantimicag.2011.09.015_bib0110) 2006; 21 Lamaris (10.1016/j.ijantimicag.2011.09.015_bib0065) 2008; 198 Cuffini (10.1016/j.ijantimicag.2011.09.015_bib0095) 2001; 37 Banche (10.1016/j.ijantimicag.2011.09.015_bib0090) 2010; 36 10.1016/j.ijantimicag.2011.09.015_bib0080 Cohen (10.1016/j.ijantimicag.2011.09.015_bib0015) 1997; 62 Richardson (10.1016/j.ijantimicag.2011.09.015_bib0035) 1992; 11 Tullio (10.1016/j.ijantimicag.2011.09.015_bib0120) 2003; 15 Tullio (10.1016/j.ijantimicag.2011.09.015_bib0100) 2008; 21 |
| References_xml | – volume: 51 start-page: S30 year: 2005 end-page: S36 ident: bib0005 article-title: Systemic fungal infections in renal diseases publication-title: J Postgrad Med – volume: 47 start-page: 226 year: 2008 end-page: 235 ident: bib0070 article-title: Immunocompromised hosts: immunopharmacology of modern antifungals publication-title: Clin Infect Dis – volume: 21 start-page: 160 year: 2006 end-page: 165 ident: bib0110 article-title: Effects of uraemia and dialysis modality on polymorphonuclear cell apoptosis and function publication-title: Nephrol Dial Transplant – volume: 39 start-page: 99 year: 2001 end-page: 103 ident: bib0040 article-title: The interaction of human monocytes, monocyte-derived macrophages, and polymorphonuclear neutrophils with caspofungin (MK-0991), an echinocandin, for antifungal activity against publication-title: Diagn Microbiol Infect Dis – volume: 36 start-page: 319 year: 2010 end-page: 323 ident: bib0090 article-title: Synergistic effect of erythromycin on polymorphonuclear cell antibacterial activity against erythromycin-resistant phenotypes of publication-title: Int J Antimicrob Agents – volume: 62 start-page: S79 year: 1997 end-page: S82 ident: bib0015 article-title: Immune dysfunction in uremia publication-title: Kidney Int Suppl – volume: 46 start-page: 212 year: 2009 end-page: 229 ident: bib0055 article-title: Recent advances in antifungal prevention and treatment publication-title: Semin Hematol – volume: 11 start-page: 22 year: 1992 end-page: 26 ident: bib0035 article-title: Effect of cilofungin on phagocytosis and intracellular killing of publication-title: Eur J Clin Microbiol Infect Dis – volume: 54 start-page: 3964 year: 2010 end-page: 3966 ident: bib0075 article-title: Synergy of caspofungin with human polymorphonuclear granulocytes for killing publication-title: Antimicrob Agents Chemother – volume: 198 start-page: 186 year: 2008 end-page: 192 ident: bib0065 article-title: Caspofungin-mediated β-glucan unmasking and enhancement of human polymorphonuclear neutrophil activity against publication-title: J Infect Dis – volume: 43 start-page: 491 year: 1999 end-page: 496 ident: bib0060 article-title: Collaboration of human phagocytes with LY 303366 for antifungal activity against publication-title: J Antimicrob Chemother – year: 2010 ident: bib0125 article-title: Caspofungin resets the depressed killing activity of polymorphonuclear cells from renal transplant recipients against publication-title: XLVII European Renal Association–European Dialysis and Transplant Association (ERA–EDTA) Congress – volume: 27 start-page: 357 year: 2005 end-page: 360 ident: bib0025 article-title: Phagocytic polymorphonuclear function in patients with progressive uremia and the effect of acute hemodialysis publication-title: Ren Fail – volume: 78 start-page: S206 year: 2001 end-page: S211 ident: bib0020 article-title: Molecular aspects of T- and B-cell function in uremia publication-title: Kidney Int Suppl – volume: 23 start-page: 729 year: 2004 end-page: 731 ident: bib0045 article-title: Effects of caspofungin (MK-0991) and anidulafungin (LY303366) on phagocytosis, oxidative burst and killing of publication-title: Eur J Clin Microbiol Infect Dis – volume: 37 start-page: 1253 year: 2001 end-page: 1259 ident: bib0095 article-title: Impact of co-amoxiclav on polymorphonuclear granulocytes from chronic hemodialysis patients publication-title: Am J Kidney Dis – volume: 28 start-page: S183 year: 2008 end-page: S187 ident: bib0030 article-title: Characteristics and causes of immune dysfunction related to uremia and dialysis publication-title: Perit Dial Int – volume: 15 start-page: 301 year: 2003 end-page: 303 ident: bib0120 article-title: Combined action of fluconazole and PMNs from uremic patients in clearing intracellular publication-title: J Chemother – volume: 22 start-page: 239 year: 2009 end-page: 242 ident: bib0105 article-title: The erythromycin-resistance in publication-title: Int J Immunopathol Pharmacol – volume: 6 start-page: 383 year: 2004 end-page: 389 ident: bib0050 article-title: Combined action of micafungin, a new echinocandin, and human phagocytes for antifungal activity against publication-title: Microbes Infect – reference: Clinical and Laboratory Standards Institute. Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard. 3rd ed. M27-A3. Wayne, PA: CLSI; 2008. – volume: 21 start-page: 153 year: 2008 end-page: 160 ident: bib0100 article-title: Role of fosfomycin tromethamine in modulating non-specific defence mechanisms in chronic uremic patients towards ESBL-producing publication-title: Int J Immunopathol Pharmacol – volume: 34 start-page: 196 year: 1990 end-page: 201 ident: bib0115 article-title: Effects of antifungal agents on the function of human neutrophils in vitro publication-title: Antimicrob Agents Chemother – volume: 47 start-page: 463 year: 2009 end-page: 467 ident: bib0010 publication-title: Med Mycol – volume: 21 start-page: 3532 year: 2006 end-page: 3538 ident: bib0085 article-title: Effect of dialysis membrane biocompatibility on polymorphonuclear granulocyte activity in dialysis patients publication-title: Nephrol Dial Transplant – volume: 28 start-page: S183 issue: Suppl. 3 year: 2008 ident: 10.1016/j.ijantimicag.2011.09.015_bib0030 article-title: Characteristics and causes of immune dysfunction related to uremia and dialysis publication-title: Perit Dial Int doi: 10.1177/089686080802803s34 – volume: 198 start-page: 186 year: 2008 ident: 10.1016/j.ijantimicag.2011.09.015_bib0065 article-title: Caspofungin-mediated β-glucan unmasking and enhancement of human polymorphonuclear neutrophil activity against Aspergillus and non-Aspergillus hyphae publication-title: J Infect Dis doi: 10.1086/589305 – volume: 21 start-page: 153 year: 2008 ident: 10.1016/j.ijantimicag.2011.09.015_bib0100 article-title: Role of fosfomycin tromethamine in modulating non-specific defence mechanisms in chronic uremic patients towards ESBL-producing Escherichia coli publication-title: Int J Immunopathol Pharmacol doi: 10.1177/039463200802100117 – volume: 21 start-page: 160 year: 2006 ident: 10.1016/j.ijantimicag.2011.09.015_bib0110 article-title: Effects of uraemia and dialysis modality on polymorphonuclear cell apoptosis and function publication-title: Nephrol Dial Transplant doi: 10.1093/ndt/gfi095 – volume: 23 start-page: 729 year: 2004 ident: 10.1016/j.ijantimicag.2011.09.015_bib0045 article-title: Effects of caspofungin (MK-0991) and anidulafungin (LY303366) on phagocytosis, oxidative burst and killing of Candida albicans by human phagocytes publication-title: Eur J Clin Microbiol Infect Dis doi: 10.1007/s10096-004-1171-z – volume: 78 start-page: S206 year: 2001 ident: 10.1016/j.ijantimicag.2011.09.015_bib0020 article-title: Molecular aspects of T- and B-cell function in uremia publication-title: Kidney Int Suppl doi: 10.1046/j.1523-1755.59.s78.6.x – volume: 54 start-page: 3964 year: 2010 ident: 10.1016/j.ijantimicag.2011.09.015_bib0075 article-title: Synergy of caspofungin with human polymorphonuclear granulocytes for killing Candida albicans publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.01780-09 – volume: 27 start-page: 357 year: 2005 ident: 10.1016/j.ijantimicag.2011.09.015_bib0025 article-title: Phagocytic polymorphonuclear function in patients with progressive uremia and the effect of acute hemodialysis publication-title: Ren Fail doi: 10.1081/JDI-200065223 – volume: 51 start-page: S30 issue: Suppl. 1 year: 2005 ident: 10.1016/j.ijantimicag.2011.09.015_bib0005 article-title: Systemic fungal infections in renal diseases publication-title: J Postgrad Med – ident: 10.1016/j.ijantimicag.2011.09.015_bib0080 – volume: 11 start-page: 22 year: 1992 ident: 10.1016/j.ijantimicag.2011.09.015_bib0035 article-title: Effect of cilofungin on phagocytosis and intracellular killing of Candida albicans by human neutrophils publication-title: Eur J Clin Microbiol Infect Dis doi: 10.1007/BF01971266 – volume: 39 start-page: 99 year: 2001 ident: 10.1016/j.ijantimicag.2011.09.015_bib0040 article-title: The interaction of human monocytes, monocyte-derived macrophages, and polymorphonuclear neutrophils with caspofungin (MK-0991), an echinocandin, for antifungal activity against Aspergillus fumigatus publication-title: Diagn Microbiol Infect Dis doi: 10.1016/S0732-8893(00)00236-4 – volume: 15 start-page: 301 year: 2003 ident: 10.1016/j.ijantimicag.2011.09.015_bib0120 article-title: Combined action of fluconazole and PMNs from uremic patients in clearing intracellular Candida albicans publication-title: J Chemother doi: 10.1179/joc.2003.15.3.301 – volume: 22 start-page: 239 year: 2009 ident: 10.1016/j.ijantimicag.2011.09.015_bib0105 article-title: The erythromycin-resistance in S. pyogenes does not limit the human polymorphonuclear cell antimicrobial activity publication-title: Int J Immunopathol Pharmacol doi: 10.1177/039463200902200127 – volume: 46 start-page: 212 year: 2009 ident: 10.1016/j.ijantimicag.2011.09.015_bib0055 article-title: Recent advances in antifungal prevention and treatment publication-title: Semin Hematol doi: 10.1053/j.seminhematol.2009.03.003 – volume: 37 start-page: 1253 year: 2001 ident: 10.1016/j.ijantimicag.2011.09.015_bib0095 article-title: Impact of co-amoxiclav on polymorphonuclear granulocytes from chronic hemodialysis patients publication-title: Am J Kidney Dis doi: 10.1053/ajkd.2001.24530 – volume: 34 start-page: 196 year: 1990 ident: 10.1016/j.ijantimicag.2011.09.015_bib0115 article-title: Effects of antifungal agents on the function of human neutrophils in vitro publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.34.2.196 – volume: 47 start-page: 463 year: 2009 ident: 10.1016/j.ijantimicag.2011.09.015_bib0010 article-title: Candida bloodstream infections in hemodialysis recipients publication-title: Med Mycol doi: 10.1080/13693780802369332 – volume: 47 start-page: 226 year: 2008 ident: 10.1016/j.ijantimicag.2011.09.015_bib0070 article-title: Immunocompromised hosts: immunopharmacology of modern antifungals publication-title: Clin Infect Dis doi: 10.1086/589290 – volume: 43 start-page: 491 year: 1999 ident: 10.1016/j.ijantimicag.2011.09.015_bib0060 article-title: Collaboration of human phagocytes with LY 303366 for antifungal activity against Aspergillus fumigatus publication-title: J Antimicrob Chemother doi: 10.1093/jac/43.4.491 – year: 2010 ident: 10.1016/j.ijantimicag.2011.09.015_bib0125 article-title: Caspofungin resets the depressed killing activity of polymorphonuclear cells from renal transplant recipients against Candida albicans – volume: 21 start-page: 3532 year: 2006 ident: 10.1016/j.ijantimicag.2011.09.015_bib0085 article-title: Effect of dialysis membrane biocompatibility on polymorphonuclear granulocyte activity in dialysis patients publication-title: Nephrol Dial Transplant doi: 10.1093/ndt/gfl415 – volume: 36 start-page: 319 year: 2010 ident: 10.1016/j.ijantimicag.2011.09.015_bib0090 article-title: Synergistic effect of erythromycin on polymorphonuclear cell antibacterial activity against erythromycin-resistant phenotypes of Streptococcus pyogenes publication-title: Int J Antimicrob Agents doi: 10.1016/j.ijantimicag.2010.06.041 – volume: 62 start-page: S79 year: 1997 ident: 10.1016/j.ijantimicag.2011.09.015_bib0015 article-title: Immune dysfunction in uremia publication-title: Kidney Int Suppl – volume: 6 start-page: 383 year: 2004 ident: 10.1016/j.ijantimicag.2011.09.015_bib0050 article-title: Combined action of micafungin, a new echinocandin, and human phagocytes for antifungal activity against Aspergillus fumigatus publication-title: Microbes Infect doi: 10.1016/j.micinf.2003.12.010 |
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| Snippet | Phagocyte-dependent cellular immunity in chronic kidney disease patients undergoing haemodialysis treatment is frequently impaired owing to the uraemic state,... Abstract Phagocyte-dependent cellular immunity in chronic kidney disease patients undergoing haemodialysis treatment is frequently impaired owing to the... |
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| SubjectTerms | Adult Aged Aged, 80 and over Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibiotics. Antiinfectious agents. Antiparasitic agents antifungal agents Antifungal Agents - immunology Antifungal Agents - pharmacology Antifungal Agents - therapeutic use antifungal properties Biological and medical sciences blood Candida albicans Candida albicans - drug effects Candida albicans - immunology Candidiasis - drug therapy Candidiasis - immunology Caspofungin cell-mediated immunity Drug Synergism Echinocandins - immunology Echinocandins - pharmacology Echinocandins - therapeutic use Emergency and intensive care: renal failure. Dialysis management Female Haemodialysis patients Humans Immunity, Innate - drug effects Immunity, Innate - immunology Infectious Disease Intensive care medicine Intracellular killing kidney diseases Kidney Failure, Chronic - therapy Lipopeptides Male Medical sciences Microbial Sensitivity Tests Middle Aged minimum inhibitory concentration mortality Neutrophils - drug effects Neutrophils - immunology Neutrophils - pathology patients phagocytes Phagocytosis Phagocytosis - drug effects Phagocytosis - immunology Pharmacology. Drug treatments PMNs Polymorphonuclear cells Renal Dialysis synergism therapeutics yeasts |
| Title | Role of caspofungin in restoring the impaired phagocyte-dependent innate immunity towards Candida albicans in chronic haemodialysis patients |
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