Torquetenovirus detection in exosomes enriched vesicles circulating in human plasma samples

• Published in: Virology journal Vol. 15; no. 1; p. 145
• Main Authors: Martelli, Francesco, Macera, Lisa, Spezia, Pietro Giorgio, Medici, Chiara, Pistello, Mauro, Guasti, Daniele, Romagnoli, Paolo, Maggi, Fabrizio, Giannecchini, Simone
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.09.2018; BioMed Central; BMC
• Subjects: Anelloviridae; Anelloviruses; Annexin II; CD63 antigen; CD81 antigen; Centrifugation; Deoxyribonuclease; deoxyribonucleases; Detergents; DNA; DNA viral load; Electron microscopy; Exosomes; freeze-thaw cycles; Freezing; Genetic aspects; hepatitis C; HIV; HIV infections; HIV, transplant recipients; Human immunodeficiency virus; kidney transplant; Kidney transplantation; Nanoparticles; Patients; Physiological aspects; polymerase chain reaction; Quantitation; Thawing; Torquetenovirus; vertebrate viruses; Vesicles; Viral genetics; viral load; Viral persistence; Viremia; Western blotting; Italy; DNA viral load; Exosomes; Torquetenovirus; Viral persistence; Anelloviruses; HIV, transplant recipients

Torquetenovirus (TTV) belongs to Anelloviridae family, infects nearly all people indefinitely without causing overt disease establishing a fine and successful interaction with the host. Increasing evidence have shown some human viruses exploit extracellular vesicles thereby helping viral persistence...