Increased supply from blood vessels promotes the activation of dormant primordial follicles in mouse ovaries

• Published in: Journal of Reproduction and Development Vol. 66; no. 2; pp. 105 - 113
• Main Authors: KOMATSU, Kouji, MASUBUCHI, Satoru
• Format: Journal Article
• Language: English
• Published: Japan The Society for Reproduction and Development 2020; Japan Science and Technology Agency
• Subjects: Angiogenesis; Animals; Biodegradability; Blood vessels; Cell culture; Estrus cycle; Female; Follicles; Gels; Granulosa cells; Mice; Neovascularization, Physiologic - physiology; Oocytes; Oogenesin 1; Original; Ovarian Follicle - blood supply; Ovarian Follicle - physiology; Ovaries; Ovary; Ovary - blood supply; Ovary - physiology; Ovulation; Ovulation - physiology; Primordial follicle; Signal Transduction; Vascular endothelial growth factor; Angiogenesis; Ovary; Primordial follicle; Oogenesin 1

The controlled activation of dormant primordial follicles is important for the maintenance of periodic ovulation. Previous reports have clearly identified the signaling pathway in granulosa cells and oocytes that controls the activation of primordial follicles; however, the exact cue for the in vivo...