HPV16 persistent infection and recurrent disease after LEEP

• Published in: Virology journal Vol. 16; no. 1; p. 148
• Main Authors: Bruno, Maria Teresa, Cassaro, Nazzario, Garofalo, Salvatore, Boemi, Sara
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.11.2019; BioMed Central; BMC
• Subjects: Analysis; Care and treatment; Case studies; chronic diseases; CIN2; computer software; descriptive statistics; Electrosurgery - methods; Female; Follow-Up Studies; genotype; Genotype & phenotype; Genotypes; Genotyping; Health aspects; Human papillomavirus; Human papillomavirus 16 - isolation & purification; Humans; Illinois; Infection; Infections; Italy - epidemiology; LEEP; Lesions; Medical research; odds ratio; Papillomavirus; Papillomavirus infection; Papillomavirus infections; Papillomavirus Infections - epidemiology; Papillomavirus Infections - surgery; Papillomavirus Infections - virology; patients; Persistent infection; Positive margin; prediction; Recurrence; Recurrence (Disease); Recurrent desease; Recurrent infection; Relapse; Retrospective Studies; Risk Factors; Squamous Intraepithelial Lesions - epidemiology; Squamous Intraepithelial Lesions - surgery; Squamous Intraepithelial Lesions - virology; standard deviation; Statistical analysis; women; Womens health; Italy; United States > US; Utah; Illinois; Papillomavirus infection; Recurrent desease; Relapse; CIN2; LEEP; Positive margin

About 23% of patients develop CIN2+ after LEEP treatment due to residual or recurrent lesions. The majority of patients with HPV infection were HPV negative before treatment, but 16,4% were still HPV 16 positive after treatment, indicating that conization do not necessarily clear HPV infection rapid...