Advancing understanding of affect labeling with dynamic causal modeling

• Published in: NeuroImage (Orlando, Fla.) Vol. 82; pp. 481 - 488
• Main Authors: Torrisi, Salvatore J., Lieberman, Matthew D., Bookheimer, Susan Y., Altshuler, Lori L.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 15.11.2013; Elsevier; Elsevier Limited
• Subjects: Accuracy; Adult; Affect - physiology; Affect labeling; Bayes Theorem; Behavior; Biological and medical sciences; Brain - physiology; Brain Mapping; Dynamic causal modeling; Effective connectivity; Emotions; Female; Fundamental and applied biological sciences. Psychology; Humans; Image Processing, Computer-Assisted; Incidental emotion regulation; Labeling; Magnetic Resonance Imaging; Male; Medical imaging; Photic Stimulation; Studies; Teenagers; Vertebrates: nervous system and sense organs; Incidental emotion regulation; Dynamic causal modeling; Affect labeling; Effective connectivity
• ISSN: 1053-8119; 1095-9572; 1095-9572
• DOI: 10.1016/j.neuroimage.2013.06.025

Mechanistic understandings of forms of incidental emotion regulation have implications for basic and translational research in the affective sciences. In this study we applied Dynamic Causal Modeling (DCM) for fMRI to a common paradigm of labeling facial affect to elucidate prefrontal to subcortical influences. Four brain regions were used to model affect labeling, including right ventrolateral prefrontal cortex (vlPFC), amygdala and Broca's area. 64 models were compared, for each of 45 healthy subjects. Family level inference split the model space to a likely driving input and Bayesian Model Selection within the winning family of 32 models revealed a strong pattern of endogenous network connectivity. Modulatory effects of labeling were most prominently observed following Bayesian Model Averaging, with the dampening influence on amygdala originating from Broca's area but much more strongly from right vlPFC. These results solidify and extend previous correlation and regression-based estimations of negative corticolimbic coupling. •Evidence suggests that affect labeling is a form of incidental emotion regulation.•We examined effective connectivity during affect labeling.•Bayesian Model Selection suggests a minimal endogenous network.•Bayesian Model Averaging showed a dampening effect from right vlPFC to amygdala.•A weaker but significant dampening also originates from the left Broca's area.