Brain diffusion alterations in patients with COVID-19 pathology and neurological manifestations

• Published in: NeuroImage clinical Vol. 37; p. 103338
• Main Authors: Caroli, Anna, Capelli, Serena, Napolitano, Angela, Cabrini, Giulia, Arrigoni, Alberto, Pezzetti, Giulio, Previtali, Mattia, Longhi, Luca Giovanni, Zangari, Rosalia, Lorini, Ferdinando Luca, Sessa, Maria, Remuzzi, Andrea, Gerevini, Simonetta
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2023; The Author(s). Published by Elsevier Inc; Elsevier
• Subjects: ADC; Brain - pathology; COVID-19; COVID-19 - complications; COVID-19 - diagnostic imaging; COVID-19 - pathology; Diffusion Magnetic Resonance Imaging - methods; Diffusion weighted imaging; Female; Gray Matter; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuroinflammation; Radiology; ADC; GM; EM; Neuroinflammation; CM; BAL; COVID-19; ACE2; SARS-CoV-2; CTRL; OD; RT-PCR; WM; DWI; DTI; FLAIR; Diffusion weighted imaging; NM; Apparent Diffusion Coefficient; Neuromuscular Disorders; Encephalitis and Meningitis; FLuid-Attenuated Inversion Recovery; Coronavirus Disease 2019; Olfactory Disorders; Angiotensin Converting Enzyme 2; Controls; BronchoAlveolar Lavage; White Matter; Cognitive and Memory disorders; Gray Matter; Real-Time Reverse-Transcriptase Polymerase-Chain-Reaction; Diffusion Tensor Imaging; Diffusion Weighted Imaging; Severe Acute Respiratory Syndrome CoronaVirus 2
• ISSN: 2213-1582; 2213-1582
• DOI: 10.1016/j.nicl.2023.103338

[Display omitted] •Brain diffusivity is increased in COVID-19 patients, mainly in white matter.•Hospitalized patients show higher diffusivity than non-hospitalized patients.•Brain diffusivity is significantly correlated with the time from COVID-19 onset. COVID-19 neurological manifestations have bee...