Smoking-induced change in intrasynaptic dopamine concentration: Effect of treatment for Tobacco Dependence

• Published in: Psychiatry research. Neuroimaging Vol. 183; no. 3; pp. 218 - 224
• Main Authors: Brody, Arthur L., London, Edythe D., Olmstead, Richard E., Allen-Martinez, Zoe, Shulenberger, Stephanie, Costello, Matthew R., Abrams, Anna L., Scheibal, David, Farahi, Judah, Shoptaw, Steven, Mandelkern, Mark A.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 30.09.2010
• Subjects: 11C-raclopride; Adult; Aged; Analysis of Variance; Bupropion - therapeutic use; Cigarette craving; Dopamine; Dopamine - metabolism; Dopamine Antagonists - pharmacokinetics; Dopamine Uptake Inhibitors - therapeutic use; Double-Blind Method; Female; Humans; Magnetic Resonance Imaging - methods; Male; Middle Aged; Positron emission tomography; Positron-Emission Tomography - methods; Psychiatry; Raclopride - pharmacokinetics; Radiology; Smoking - metabolism; Smoking - psychology; Statistics as Topic; Synapses - diagnostic imaging; Synapses - metabolism; Tobacco Dependence; Tobacco Use Disorder - diagnostic imaging; Tobacco Use Disorder - drug therapy; Ventral striatum; Young Adult; 11C-raclopride; Ventral striatum; Dopamine; Positron emission tomography; Cigarette craving; Tobacco Dependence

The aim of this study was to determine whether standard treatments for Tobacco Dependence affect smoking-induced changes in intrasynaptic dopamine (DA) concentration. Forty-three otherwise healthy adult cigarette smokers (10 to 40 cigarettes per day) were treated with either practical group counseli...