Suction blistering the lesional skin of vitiligo patients reveals useful biomarkers of disease activity

• Published in: Journal of the American Academy of Dermatology Vol. 76; no. 5; pp. 847 - 855.e5
• Main Authors: Strassner, James P., Rashighi, Mehdi, Ahmed Refat, Maggi, Richmond, Jillian M., Harris, John E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2017
• Subjects: Adolescent; Adult; autoimmunity; biomarkers; Biomarkers - metabolism; biopsy; Blister - metabolism; blisters; Case-Control Studies; CD8; CD8-Positive T-Lymphocytes; Chemokine CXCL10 - metabolism; Chemokine CXCL11 - metabolism; Chemokine CXCL9 - metabolism; CXCL10; CXCL9; Dermatology; Female; Humans; inflammatory skin disease; Interferon-gamma - metabolism; Lymphocyte Count; Male; Middle Aged; Receptors, CXCR3 - metabolism; ROC Curve; Suction; suction blister; vitiligo; Vitiligo - immunology; Vitiligo - metabolism; Young Adult; CXCL; CXCL9; biomarkers; inflammatory skin disease; ROC; vitiligo; blisters; CXCL10; IFN-γ; autoimmunity; suction blister; CD8; biopsy; CXCR; ELISA; interferon-γ; C-X-C motif chemokine receptor; C-X-C motif chemokine ligand; enzyme-linked immunosorbent assay; receiver operating characteristic

Vitiligo is an autoimmune disease of the skin with limited treatment options; there is an urgent need to identify and validate biomarkers of disease activity to support vitiligo clinical studies. To investigate potential biomarkers of disease activity directly in the skin of vitiligo subjects and he...