Trimethylamine N-oxide, a gut microbiota-dependent metabolite of choline, is positively associated with the risk of primary liver cancer: a case-control study

• Published in: Nutrition & metabolism Vol. 15; no. 1; p. 81
• Main Authors: Liu, Zhao-Yan, Tan, Xu-Ying, Li, Qi-Jiong, Liao, Gong-Cheng, Fang, Ai-Ping, Zhang, Dao-Ming, Chen, Pei-Yan, Wang, Xiao-Yan, Luo, Yun, Long, Jing-An, Zhong, Rong-Huan, Zhu, Hui-Lian
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.11.2018; BioMed Central; BMC
• Subjects: Alcohol; biomarkers; blood serum; Case control study; case-control studies; China; Choline; Colorectal cancer; confidence interval; Development and progression; Diabetes; Digestive system; Disease prevention; DNA methylation; electrospray ionization mass spectrometry; Gut microbiota metabolite; Health aspects; Health risk assessment; Hepatitis; High-performance liquid chromatography; Intestinal microflora; intestinal microorganisms; Kidney diseases; Liver cancer; liver neoplasms; Mass spectroscopy; Metabolites; Microbiota; Microbiota (Symbiotic organisms); Nutrition research; nutrition risk assessment; odds ratio; patients; Physiological aspects; prospective studies; Regression analysis; Risk factors; Serum levels; tandem mass spectrometry; Trimethylamine; Trimethylamine N-oxide (TMAO); Trimethylamine-N-oxide; China; Liver cancer; Case control study; Gut microbiota metabolite; Choline; Trimethylamine N-oxide (TMAO)

Evidence has suggested a potential link exists between trimethylamine-N-oxide (TMAO), a choline-derived metabolite produced by gut microbiota, and some cancers, but little is known for primary liver cancer (PLC). A case-control study was designed including 671 newly diagnosed PLC patients and 671 co...