The assessment of molecular dynamics results of three-dimensional RNA aptamer structure prediction

• Published in: PloS one Vol. 18; no. 7; p. e0288684
• Main Authors: Ropii, Bejo, Bethasari, Maulidwina, Anshori, Isa, Koesoema, Allya Paramita, Shalannanda, Wervyan, Satriawan, Ardianto, Setianingsih, Casi, Akbar, Mohammad Rizki, Aditama, Reza
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.07.2023
• Subjects: Analysis; Antibodies; Aptamers; Biology and life sciences; Biosensors; Cluster analysis; Clustering; DNA; Dynamic structural analysis; In vitro methods and tests; Ligands; Mathematical models; Modelling; Molecular dynamics; Molecular interactions; Monoclonal antibodies; Nucleotide sequence; Nucleotides; Pharmacology; Physical Sciences; Proteins; Research and Analysis Methods; Ribonucleic acid; RNA; Servers; Simulation; Single-stranded DNA; Sodium; Three dimensional models; Topology; Indonesia

Aptamers are single-stranded DNA or RNA that bind to specific targets such as proteins, thus having similar characteristics to antibodies. It can be synthesized at a lower cost, with no batch-to-batch variations, and is easier to modify chemically than antibodies, thus potentially being used as ther...