Neutralization of hepatitis B virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs antigen

• Published in: Nature communications Vol. 13; no. 1; pp. 5207 - 12
• Main Authors: Washizaki, Ayaka, Murayama, Asako, Murata, Megumi, Kiyohara, Tomoko, Yato, Keigo, Yamada, Norie, Aly, Hussein Hassan, Tanaka, Tomohisa, Moriishi, Kohji, Nishitsuji, Hironori, Shimotohno, Kunitada, Goh, Yasumasa, Ishii, Ken J., Yotsuyanagi, Hiroshi, Muramatsu, Masamichi, Ishii, Koji, Takahashi, Yoshimasa, Suzuki, Ryosuke, Akari, Hirofumi, Kato, Takanobu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.09.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13/109; 13/51; 14/1; 631/250/255/234/2513; 631/326/590; 631/326/596/1550; 692/4020/4021/234/2513/1549; 692/420/254; Antibodies; Antigens; Combined vaccines; Genotypes; Hepatitis; Hepatitis B; Hepatitis B surface antigen; Humanities and Social Sciences; Immunization; Morbidity; multidisciplinary; Mutation; Neutralization; Prophylaxis; Science; Science (multidisciplinary); Vaccines; Yeast

Although the current hepatitis B (HB) vaccine comprising small-HBs antigen (Ag) is potent and safe, attenuated prophylaxis against hepatitis B virus (HBV) with vaccine-escape mutations (VEMs) has been reported. We investigate an HB vaccine consisting of large-HBsAg that overcomes the shortcomings of...