A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer

• Published in: Journal of hepatology Vol. 65; no. 3; pp. 579 - 588
• Main Authors: Asgharpour, Amon, Cazanave, Sophie C., Pacana, Tommy, Seneshaw, Mulugeta, Vincent, Robert, Banini, Bubu A., Kumar, Divya Prasanna, Daita, Kalyani, Min, Hae-Ki, Mirshahi, Faridoddin, Bedossa, Pierre, Sun, Xiaochen, Hoshida, Yujin, Koduru, Srinivas V., Contaifer, Daniel, Warncke, Urszula Osinska, Wijesinghe, Dayanjan S., Sanyal, Arun J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2016
• Subjects: Animals; Carcinoma, Hepatocellular; Diet, High-Fat; Disease Models, Animal; Drug therapy; Fibrosis; Gastroenterology and Hepatology; Hepatocellular carcinoma; Hepatocyte ballooning; Humans; Liver; Liver Neoplasms; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Steatosis; T2DM; NAFLD; DIAMOND; Hepatocyte ballooning; GTT; JNK; ITT; ALT; NW; Hepatocellular carcinoma; IRE-1; PERK; FDR; Drug therapy; CD; AST; S129; SW; LDL-c; PUFA; HCC; NASH; ER; MCD; Steatosis; B6; Fibrosis; CK-18; normal water; alanine aminotransferase; insulin tolerance test; C57BL/6J; low-density lipoprotein-cholesterol; 129S1/SvImJ; c-Jun NH2-terminal kinase; protein kinase R-like endoplasmic reticulum kinase; cytokeratin-18; sugar water; methionine choline deficient; diet-induced animal model of non-alcoholic fatty liver disease; polyunsaturated fatty acid; non-alcoholic steatohepatitis; glucose tolerance test; non-alcoholic fatty liver disease; type 2 diabetes mellitus; inositol-requiring enzyme-1; false discovery rate; chow diet; aspartate aminotransferase; hepatocellular carcinoma, WD, Western diet; endoplasmic reticulum

[Display omitted] The lack of a preclinical model of progressive non-alcoholic steatohepatitis (NASH) that recapitulates human disease is a barrier to therapeutic development. A stable isogenic cross between C57BL/6J (B6) and 129S1/SvImJ (S129) mice were fed a high fat diet with ad libitum consumpti...