In vivo detection of neuropathologic changes in presymptomatic MAPT mutation carriers: A PET and MRI study - Miyoshi, Michie; Shinotoh, Hitoshi; Wszolek, Zbigniew K.; Strongosky, Audrey J.; Shimada, Hitoshi; Arakawa, Ryosuke; Higuchi, Makoto; Ikoma, Yoko; Yasuno, Fumihiko; Fukushi, Kiyoshi; Irie, Toshiaki; Ito, Hiroshi; et al. (Parkinsonism & related disorders, 2010)
Keywords: Acetylcholine; Adult; Brain - diagnostic imaging; Brain - pathology; Dopamine; Frontotemporal Dementia - diagnostic imaging; Frontotemporal Dementia - genetics; Frontotemporal Dementia - pathology; FTDP-17; Heterozygote; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Microglia; Mutation; Neurology; Neuropsychological Tests; Positron emission tomography; tau Proteins - genetics; AChE; PBR; Dopamine; MRI; PBBS; k ref; [ 11C]dopa; PGC; BP ND; Microglia; PPND; Magnetic resonance imaging; MP4A; FTDP-17; Acetylcholine; Positron emission tomography; PET; k 3; pallidopontonigral degeneration; binding potential; hydrolysis rate constant; presymptomatic gene carrier; peripheral benzodiazepine binding site; frontotemporal dementia with parkinsonism linked to chromosome 17; acetylcholinesterase; an index of dopamine synthesis; [ 11C] N-methylpiperidin-4-yl acetate; peripheral benzodiazepine receptor; l-[β- 11C]dopa