Decay of Fc-dependent antibody functions after mild to moderate COVID-19

• Published in: Cell reports. Medicine Vol. 2; no. 6; p. 100296
• Main Authors: Lee, Wen Shi, Selva, Kevin John, Davis, Samantha K., Wines, Bruce D., Reynaldi, Arnold, Esterbauer, Robyn, Kelly, Hannah G., Haycroft, Ebene R., Tan, Hyon-Xhi, Juno, Jennifer A., Wheatley, Adam K., Hogarth, P. Mark, Cromer, Deborah, Davenport, Miles P., Chung, Amy W., Kent, Stephen J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.06.2021; Elsevier
• Subjects: ADCC; ADP; Advanced Basic Science; Antibodies, Viral - blood; Antibodies, Viral - metabolism; antibody; Antibody-Dependent Cell Cytotoxicity - immunology; Cell Line, Tumor; convalescence; COVID-19; COVID-19 - immunology; COVID-19 - pathology; COVID-19 - virology; decay; Dimerization; Fc effector functions; Humans; Immunoglobulin Fc Fragments - genetics; Immunoglobulin Fc Fragments - immunology; Immunoglobulin Fc Fragments - metabolism; Kinetics; Neutralization Tests; Phagocytosis; SARS-CoV-2; SARS-CoV-2 - immunology; SARS-CoV-2 - isolation & purification; SARS-CoV-2 - metabolism; Severity of Illness Index; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Spike Glycoprotein, Coronavirus - metabolism; trogocytosis; COVID-19; trogocytosis; phagocytosis; SARS-CoV-2; Fc effector functions; convalescence; antibody; decay; ADCC; ADP

The capacity of antibodies to engage with immune cells via the Fc region is important in preventing and controlling many infectious diseases. The evolution of such antibodies during convalescence from coronavirus disease 2019 (COVID-19) is largely unknown. We develop assays to measure Fc-dependent a...