HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration

• Published in: Nature (London) Vol. 498; no. 7454; pp. 376 - 379
• Main Authors: Cooper, Arik, García, Mayra, Petrovas, Constantinos, Yamamoto, Takuya, Koup, Richard A., Nabel, Gary J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.06.2013; Nature Publishing Group
• Subjects: 631/326/421; Carrier State - virology; CD4 lymphocytes; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - metabolism; CD4-Positive T-Lymphocytes - pathology; CD4-Positive T-Lymphocytes - virology; Cell death; Cell Death - drug effects; Cell Line; Cell Survival - drug effects; Cells, Cultured; DNA Damage; DNA Repair; DNA-Activated Protein Kinase - antagonists & inhibitors; DNA-Activated Protein Kinase - metabolism; Enzyme Activation; Histones - metabolism; HIV infection; HIV Infections - pathology; HIV Infections - virology; HIV Integrase Inhibitors - pharmacology; HIV-1 - drug effects; HIV-1 - growth & development; HIV-1 - pathogenicity; Human immunodeficiency virus 1; Human Immunodeficiency Virus Proteins - analysis; Human Immunodeficiency Virus Proteins - genetics; Humanities and Social Sciences; Humans; letter; Macaca; multidisciplinary; Observations; Phosphorylation; Properties; Protein kinases; Proviruses - pathogenicity; Pyrrolidinones - pharmacology; Raltegravir Potassium; Science; Testing; Tumor Suppressor Protein p53 - metabolism; Virus Integration; Virus Replication - drug effects; United States

HIV-1 causes CD4 + T-cell death through viral integration by stimulation of DNA-dependent protein kinase (DNA-PK), a protein known to act in the p53 damage response pathway for double-stranded DNA breaks, in activated cells. How HIV-1 causes cell death It is known that CD4 + helper T cells, key immu...