HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration - Cooper, Arik; García, Mayra; Petrovas, Constantinos; Yamamoto, Takuya; Koup, Richard A.; Nabel, Gary J. (Nature (London), 2013)
Keywords: 631/326/421; Carrier State - virology; CD4 lymphocytes; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - metabolism; CD4-Positive T-Lymphocytes - pathology; CD4-Positive T-Lymphocytes - virology; Cell death; Cell Death - drug effects; Cell Line; Cell Survival - drug effects; Cells, Cultured; DNA Damage; DNA Repair; DNA-Activated Protein Kinase - antagonists & inhibitors; DNA-Activated Protein Kinase - metabolism; Enzyme Activation; Histones - metabolism; HIV infection; HIV Infections - pathology; HIV Infections - virology; HIV Integrase Inhibitors - pharmacology; HIV-1 - drug effects; HIV-1 - growth & development; HIV-1 - pathogenicity; Human immunodeficiency virus 1; Human Immunodeficiency Virus Proteins - analysis; Human Immunodeficiency Virus Proteins - genetics; Humanities and Social Sciences; Humans; letter; Macaca; multidisciplinary; Observations; Phosphorylation; Properties; Protein kinases; Proviruses - pathogenicity; Pyrrolidinones - pharmacology; Raltegravir Potassium; Science; Testing; Tumor Suppressor Protein p53 - metabolism; Virus Integration; Virus Replication - drug effects; United States