The Increasing Incidence of Young-Onset Colorectal Cancer: A Call to Action

• Published in: Mayo Clinic proceedings Vol. 89; no. 2; pp. 216 - 224
• Main Authors: Ahnen, Dennis J., MD, Wade, Sally W., MPH, Jones, Whitney F., MD, Sifri, Randa, MD, Mendoza Silveiras, Jose, MD, Greenamyer, Jasmine, MPH, Guiffre, Stephanie, MPA, Axilbund, Jennifer, MS, Spiegel, Andrew, JD, You, Y. Nancy, MD, MHSc
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.02.2014; Elsevier, Inc; Elsevier Limited
• Subjects: Adolescent; Adult; Age of Onset; Aged; Aged, 80 and over; Cancer; Care and treatment; Colorectal cancer; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - mortality; Diagnosis; Female; Health aspects; Humans; Incidence; Internal Medicine; Male; Middle Aged; Prevention; Registries; Risk factors; Survival Rate; United States - epidemiology; United States; colorectal cancer; annual percent change; HR; MSS; primary care physician; APC; FAP; CRC; FDR; first-degree relative; hazard ratio; SEER; Surveillance, Epidemiology, and End Results; familial adenomatous polyposis; microsatellite stable; PCP

Abstract In the United States, colorectal cancer (CRC) is the third most common and second most lethal cancer. More than one-tenth of CRC cases (11% of colon cancers and 18% of rectal cancers) have a young onset (ie, occurring in individuals younger than 50 years). The CRC incidence and mortality ra...