Single-subject classification of presymptomatic frontotemporal dementia mutation carriers using multimodal MRI

• Published in: NeuroImage clinical Vol. 20; pp. 188 - 196
• Main Authors: Feis, Rogier A., Bouts, Mark J.R.J., Panman, Jessica L., Jiskoot, Lize C., Dopper, Elise G.P., Schouten, Tijn M., de Vos, Frank, van der Grond, Jeroen, van Swieten, John C., Rombouts, Serge A.R.B.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2018; Elsevier
• Subjects: Adult; Asymptomatic Diseases - classification; C9orf72, human; classification; Diffusion Tensor Imaging; Diffusion Tensor Imaging - classification; Diffusion Tensor Imaging - methods; Female; Frontotemporal dementia; Frontotemporal Dementia - classification; Frontotemporal Dementia - diagnostic imaging; Frontotemporal Dementia - genetics; GRN protein, human; Heterozygote; Humans; machine learning; Magnetic Resonance Imaging - classification; Magnetic Resonance Imaging - methods; Male; MAPT protein, human; Middle Aged; Multimodal Imaging - classification; Multimodal Imaging - methods; Multimodal MRI; Mutation - genetics; Radiology; Regular; Resting-state functional MRI; Retrospective Studies; FCor; MAPT protein, human; GRN; 3DT1w; AxD; AUC; Pcor; MMSE; WM; DWI; MD; Multimodal MRI; GMD; (rs-f)MRI; GRN protein, human; GM; ICA; ROC; TBSS; classification; machine learning; Diffusion Tensor Imaging; (bv)FTD; WMD; RD; C9orf72, human; DTI; Resting-state functional MRI; FA; MAPT; Frontotemporal dementia; C9orf72; Radial diffusivity; Area under the receiver operating characteristics curve; Progranulin; Sparse L1-regularised partial correlations; White matter; Axial diffusivity; Fractional anisotropy; Chromosome 9 open reading frame 72; Full correlations; Receiver operating characteristics; Grey matter density; (resting-state functional) Magnetic resonance imaging; Diffusion-weighted imaging; Mean diffusivity; (behavioural variant) Frontotemporal dementia; 3DT 1w; 3-dimensional T 1-weighted; Microtubule-associated protein Tau; White matter density; Mini-mental state examination; Tract-based spatial statistics; Grey matter; Independent component analysis; ROC, Receiver operating characteristics; 3DT1w, 3-dimensional T1-weighted; FA, Fractional anisotropy; GM, Grey matter; GRN, Progranulin; ICA, Independent component analysis; DTI, Diffusion tensor imaging; MD, Mean diffusivity; DWI, Diffusion-weighted imaging; FCor, Full correlations; (bv)FTD, (behavioural variant) Frontotemporal dementia; WMD, White matter density; GMD, Grey matter density; MAPT, Microtubule-associated protein Tau; TBSS, Tract-based spatial statistics; WM, White matter; C9orf72, Chromosome 9 open reading frame 72; AUC, Area under the receiver operating characteristics curve; AxD, Axial diffusivity; MMSE, Mini-mental state examination; (rs-f)MRI, (resting-state functional) Magnetic resonance imaging; RD, Radial diffusivity; Pcor, Sparse L1-regularised partial correlations

Classification models based on magnetic resonance imaging (MRI) may aid early diagnosis of frontotemporal dementia (FTD) but have only been applied in established FTD cases. Detection of FTD patients in earlier disease stages, such as presymptomatic mutation carriers, may further advance early diagn...