Peptidoglycan recognition protein (PGRP)-LE and PGRP-LC act synergistically in Drosophila immunity

• Published in: The EMBO journal Vol. 23; no. 23; pp. 4690 - 4700
• Main Authors: Takehana, Aya, Yano, Tamaki, Mita, Shizuka, Kotani, Atsushi, Oshima, Yoshiteru, Kurata, Shoichiro
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 24.11.2004; Blackwell Publishing Ltd; Nature Publishing Group
• Subjects: Animals; antibacterial defense; Bacillus megaterium; Bacteria; Carrier Proteins - genetics; Carrier Proteins - immunology; Drosophila; Drosophila - immunology; Drosophila - microbiology; Drosophila Proteins - biosynthesis; Drosophila Proteins - genetics; Drosophila Proteins - immunology; E coli; Epithelium - immunology; Epithelium - metabolism; Escherichia coli; Gene Expression Regulation; innate immunity; Microorganisms; Mutation; non-self recognition; Pattern recognition; Peptides; Peptides - genetics; Peptides - immunology; PGRP; Upstream

In innate immunity, pattern recognition molecules recognize cell wall components of microorganisms and activate subsequent immune responses, such as the induction of antimicrobial peptides and melanization in Drosophila. The diaminopimelic acid (DAP)‐type peptidoglycan potently activates imd‐depende...