Activation of autophagy inhibits nucleotide‐binding oligomerization domain‐like receptor protein 3 inflammasome activation and attenuates myocardial ischemia‐reperfusion injury in diabetic rats

• Published in: Journal of diabetes investigation Vol. 11; no. 5; pp. 1126 - 1136
• Main Authors: Zhang, Dengwen, He, Yi, Ye, Xiaodong, Cai, Yin, Xu, Jindong, Zhang, Liangqing, Li, Mingyi, Liu, Hao, Wang, Sheng, Xia, Zhengyuan
• Format: Journal Article
• Language: English
• Published: Japan John Wiley & Sons, Inc 01.09.2020; John Wiley and Sons Inc; Wiley
• Subjects: Animals; Antibodies; Apoptosis; Autophagy; Cardiomyocytes; Cardiovascular disease; Caspase; Coronary artery; Creatine; Creatine kinase; Dehydrogenases; Deoxyribonucleic acid; Diabetes; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Experimental - complications; Diabetic myocardium; DNA; Glucose; Heart; Homeostasis; Hypoxia; Inflammasomes; Inflammasomes - genetics; Inflammasomes - metabolism; Inflammation; Ischemia; L-Lactate dehydrogenase; Laboratory animals; Lactic acid; Male; Myocardial ischemia; Myocardial ischemia‐reperfusion injury; Myocardial Reperfusion Injury - etiology; Myocardial Reperfusion Injury - metabolism; Myocardial Reperfusion Injury - pathology; Myocardial Reperfusion Injury - prevention & control; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors; NLR Family, Pyrin Domain-Containing 3 Protein - genetics; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Nucleotide‐binding oligomerization domain‐like receptor protein 3 inflammasome; Oligomerization; Original; Oxidative stress; Penicillin; Phagocytosis; Proteins; Rapamycin; Rats; Rats, Sprague-Dawley; Reactive oxygen species; Reactive Oxygen Species - metabolism; Reperfusion; Rodents; Signal Transduction; Streptozocin; United States > US; Diabetic myocardium; Myocardial ischemia-reperfusion injury; Nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome

Aims/Introduction Diabetic hearts are more vulnerable to ischemia‐reperfusion injury (I/RI). The activation of nucleotide‐binding oligomerization domain‐like receptor protein 3 (NLRP3) inflammasome can mediate the inflammatory process, and hence might contribute to myocardial I/RI. Activation of aut...