First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

• Published in: Journal of translational medicine Vol. 16; no. 1; pp. 142 - 9
• Main Authors: Liau, Linda M., Ashkan, Keyoumars, Tran, David D., Campian, Jian L., Trusheim, John E., Cobbs, Charles S., Heth, Jason A., Salacz, Michael, Taylor, Sarah, D’Andre, Stacy D., Iwamoto, Fabio M., Dropcho, Edward J., Moshel, Yaron A., Walter, Kevin A., Pillainayagam, Clement P., Aiken, Robert, Chaudhary, Rekha, Goldlust, Samuel A., Bota, Daniela A., Duic, Paul, Grewal, Jai, Elinzano, Heinrich, Toms, Steven A., Lillehei, Kevin O., Mikkelsen, Tom, Walbert, Tobias, Abram, Steven R., Brenner, Andrew J., Brem, Steven, Ewend, Matthew G., Khagi, Simon, Portnow, Jana, Kim, Lyndon J., Loudon, William G., Thompson, Reid C., Avigan, David E., Fink, Karen L., Geoffroy, Francois J., Lindhorst, Scott, Lutzky, Jose, Sloan, Andrew E., Schackert, Gabriele, Krex, Dietmar, Meisel, Hans-Jorg, Wu, Julian, Davis, Raphael P., Duma, Christopher, Etame, Arnold B., Mathieu, David, Kesari, Santosh, Piccioni, David, Westphal, Manfred, Baskin, David S., New, Pamela Z., Lacroix, Michel, May, Sven-Axel, Pluard, Timothy J., Tse, Victor, Green, Richard M., Villano, John L., Pearlman, Michael, Petrecca, Kevin, Schulder, Michael, Taylor, Lynne P., Maida, Anthony E., Prins, Robert M., Cloughesy, Timothy F., Mulholland, Paul, Bosch, Marnix L.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.05.2018; BioMed Central; BMC
• Subjects: Brain cancer; Cancer therapies; Cancer vaccines; Chemoradiotherapy; Clinical trials; Dendritic cell; Dendritic cells; Enrollments; Gene expression; Genetic aspects; Glioblastoma; Glioblastomas; Immunotherapy; Medical prognosis; Patients; Physiological aspects; Prevention; Radiation therapy; Surgery; Temozolomide; Vaccine; Vaccines; United States; United Kingdom; Canada; United States > US; Dendritic cell; Vaccine; Immunotherapy; Glioblastoma

Standard therapy for glioblastoma includes surgery, radiotherapy, and temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax -L) to standard therapy for newly diagnosed glioblastoma. After surgery and chemoradiotherapy, patients wer...