NK Cells Expressing the Inhibitory Killer Immunoglobulin-Like Receptors (iKIR) KIR2DL1, KIR2DL3 and KIR3DL1 Are Less Likely to Be CD16+ than Their iKIR Negative Counterparts

• Published in: PloS one Vol. 11; no. 10; p. e0164517
• Main Authors: Isitman, Gamze, Tremblay-McLean, Alexandra, Lisovsky, Irene, Bruneau, Julie, Lebouché, Bertrand, Routy, Jean-Pierre, Bernard, Nicole F.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.10.2016; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; AIDS; Antibody-Dependent Cell Cytotoxicity; Antigens; Biology and life sciences; CD16 antigen; Cell activation; Cells, Cultured; Cytotoxicity; Education; Fc receptors; GPI-Linked Proteins - analysis; GPI-Linked Proteins - immunology; Granzyme B; Histocompatibility antigen HLA; HIV; Human immunodeficiency virus; Humans; Immunoglobulin G; Immunoglobulin-like receptors; Immunoglobulins; Killer cell immunoglobulin-like receptors; Killer cells; Killer Cells, Natural - immunology; Ligands; Lymphocyte receptors; Lysis; Medicine; Medicine and health sciences; Natural killer cells; Null cells; Potassium channels (inwardly-rectifying); Receptors; Receptors, IgG - analysis; Receptors, IgG - immunology; Receptors, KIR2DL1 - analysis; Receptors, KIR2DL1 - immunology; Receptors, KIR2DL3 - analysis; Receptors, KIR2DL3 - immunology; Receptors, KIR3DL1 - analysis; Receptors, KIR3DL1 - immunology; Research and Analysis Methods; Toxicity

Natural Killer (NK) cell education, which requires the engagement of inhibitory NK cell receptors (iNKRs) by their ligands, is important for generating self-tolerant functional NK cells. While the potency of NK cell education is directly related to their functional potential upon stimulation with HL...