Effect of Aerobic Training on Walking Capacity and Maximal Exercise Tolerance in Patients With Multiple Sclerosis: A Randomized Crossover Controlled Study

Physical deconditioning is involved in the impaired exercise tolerance of patients with multiple sclerosis (MS), but data on the effects of aerobic training (AT) in this population are scanty. The purpose of this study was to compare the effects of an 8-week AT program on exercise capacity-in terms...

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Published inPhysical therapy Vol. 87; no. 5; pp. 545 - 555
Main Authors Rampello, Anais, Franceschini, Marco, Piepoli, Massimo, Antenucci, Roberto, Lenti, Gabriella, Olivieri, Dario, Chetta, Alfredo
Format Journal Article
LanguageEnglish
Published United States American Physical Therapy Association 01.05.2007
Oxford University Press
Subjects
Adult
Aerobic exercises
Care and treatment
Complications and side effects
Cross-Over Studies
Exercise
Exercise - physiology
Exercise Tolerance - physiology
Female
Health aspects
Heart Rate - physiology
Humans
Male
Mental Health
Multiple sclerosis
Multiple Sclerosis - physiopathology
Multiple Sclerosis - psychology
Multiple Sclerosis - rehabilitation
Oximetry
Oxygen Consumption - physiology
Physical fitness
Physical therapy
Quality of Life
Respiratory Function Tests
Surveys and Questionnaires
Walking
Walking - physiology
United States
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Abstract Physical deconditioning is involved in the impaired exercise tolerance of patients with multiple sclerosis (MS), but data on the effects of aerobic training (AT) in this population are scanty. The purpose of this study was to compare the effects of an 8-week AT program on exercise capacity-in terms of walking capacity and maximum exercise tolerance, as well as its effects on fatigue and health-related quality of life-as compared with neurological rehabilitation (NR) in subjects with MS. Nineteen subjects (14 female, 5 male; mean age [X+/-SD]=41+/-8 years) with mild to moderate disability secondary to MS participated in a randomized crossover controlled study. Eleven subjects (8 female, 3 male; mean age [X+/-SD]=44+/-6 years) completed the study. After AT, but not NR, the subjects' walking distances and speeds during a self-paced walk were significantly improved, as were their maximum work rate, peak oxygen uptake, and oxygen pulse during cardiopulmonary exercise tests. The increases in peak oxygen uptake and maximum work rate, but not in walking capacity, were significantly higher after AT, as compared with after NR. Additionally, the subjects who were most disabled tended to benefit more from AT. There were no differences between AT and NR in effects on fatigue, and the results showed that AT may have partially affected health-related quality of life. The results suggest that AT is more effective than NR in improving maximum exercise tolerance and walking capacity in people with mild to moderate disability secondary to MS.
AbstractList Background and Purpose Physical deconditioning is involved in the impaired exercise tolerance of patients with multiple sclerosis (MS), but data on the effects of aerobic training (AT) in this population are scanty. The purpose of this study was to compare the effects of an 8-week AT program on exercise capacity--in terms of walking capacity and maximum exercise tolerance, as well as its effects on fatigue and health-related quality of life--as compared with neurological rehabilitation (NR) in subjects with MS. Subjects and Methods Nineteen subjects (14 female, 5 male; mean age [[bar.X]±SD]=41±8 years) with mild to moderate disability secondary to MS participated in a randomized crossover controlled study. Eleven subjects (8 female, 3 male; mean age [[bar.X]±SD] =44±6 years) completed the study. Results After AT, but not NR, the subjects' walking distances and speeds during a self-paced walk were significantly improved, as were their maximum work rate, peak oxygen uptake, and oxygen pulse during cardiopulmonary exercise tests. The increases in peak oxygen uptake and maximum work rate, but not in walking capacity, were significantly higher after AT, as compared with after NR. Additionally, the subjects who were most disabled tended to benefit more from AT. There were no differences between AT and NR in effects on fatigue, and the results showed that AT may have partially affected health-related quality of life. Discussion and Conclusion The results suggest that AT is more effective than NR in improving maximum exercise tolerance and walking capacity in people with mild to moderate disability secondary to MS.
Physical deconditioning is involved in the impaired exercise tolerance of patients with multiple sclerosis (MS), but data on the effects of aerobic training (AT) in this population are scanty. The purpose of this study was to compare the effects of an 8-week AT program on exercise capacity-in terms of walking capacity and maximum exercise tolerance, as well as its effects on fatigue and health-related quality of life-as compared with neurological rehabilitation (NR) in subjects with MS. Nineteen subjects (14 female, 5 male; mean age [X+/-SD]=41+/-8 years) with mild to moderate disability secondary to MS participated in a randomized crossover controlled study. Eleven subjects (8 female, 3 male; mean age [X+/-SD]=44+/-6 years) completed the study. After AT, but not NR, the subjects' walking distances and speeds during a self-paced walk were significantly improved, as were their maximum work rate, peak oxygen uptake, and oxygen pulse during cardiopulmonary exercise tests. The increases in peak oxygen uptake and maximum work rate, but not in walking capacity, were significantly higher after AT, as compared with after NR. Additionally, the subjects who were most disabled tended to benefit more from AT. There were no differences between AT and NR in effects on fatigue, and the results showed that AT may have partially affected health-related quality of life. The results suggest that AT is more effective than NR in improving maximum exercise tolerance and walking capacity in people with mild to moderate disability secondary to MS.
Background and Purpose: Physical deconditioning is involved in the impaired exercise tolerance of patients with multiple sclerosis (MS), but data on the effects of aerobic training (AT) in this population are scanty. The purpose of this study was to compare the effects of an 8-week AT program on exercise capacity in terms of walking capacity and maximum exercise tolerance, as well as its effects on fatigue and health-related quality of life - as compared with neurological rehabilitation (NR) in subjects with MS. Subjects and Methods: Nineteen subjects (14 female, 5 male; mean age [X+/-SDI =41+/-8 years) with mild to moderate disability secondary to MS participated in a randomized crossover controlled study. Eleven subjects (8 female, 3 male; mean age [X+/-SD] =44+/-6 years) completed the study. Results: After AT, but not NR, the subjects walking distances and speeds during a self-paced walk were significantly improved, as were their maximum work rate, peak oxygen uptake, and oxygen pulse during cardiopulmonary exercise tests. The increases in peak oxygen uptake and maximum work rate, but not in walking capacity, were significantly higher after AT, as compared with after NR. Additionally, the subjects who were most disabled tended to benefit more from AT. There were no differences between AT and NR in effects on fatigue, and the results showed that AT may have partially affected health-related quality of life. Discussion and Conclusion: The results suggest that AT is more effective than NR in improving maximum exercise tolerance and walking capacity in people with mild to moderate disability secondary to MS.
Physical deconditioning is involved in the impaired exercise tolerance of patients with multiple sclerosis (MS), but data on the effects of aerobic training (AT) in this population are scanty. The purpose of this study was to compare the effects of an 8-week AT program on exercise capacity--in terms of walking capacity and maximum exercise tolerance, as well as its effects on fatigue and health-related quality of life--as compared with neurological rehabilitation (NR) in subjects with MS. Nineteen subjects (14 female, 5 male; mean age [[bar.X]±SD]=41±8 years) with mild to moderate disability secondary to MS participated in a randomized crossover controlled study. Eleven subjects (8 female, 3 male; mean age [[bar.X]±SD] =44±6 years) completed the study. After AT, but not NR, the subjects' walking distances and speeds during a self-paced walk were significantly improved, as were their maximum work rate, peak oxygen uptake, and oxygen pulse during cardiopulmonary exercise tests. The increases in peak oxygen uptake and maximum work rate, but not in walking capacity, were significantly higher after AT, as compared with after NR. Additionally, the subjects who were most disabled tended to benefit more from AT. There were no differences between AT and NR in effects on fatigue, and the results showed that AT may have partially affected health-related quality of life. The results suggest that AT is more effective than NR in improving maximum exercise tolerance and walking capacity in people with mild to moderate disability secondary to MS.
Physical deconditioning is involved in the impaired exercise tolerance of patients with multiple sclerosis (MS), but data on the effects of aerobic training (AT) in this population are scanty. The purpose of this study was to compare the effects of an 8-week AT program on exercise capacity-in terms of walking capacity and maximum exercise tolerance, as well as its effects on fatigue and health-related quality of life-as compared with neurological rehabilitation (NR) in subjects with MS. Nineteen subjects (14 female, 5 male; mean age [X±SD]=41±8 years) with mild to moderate disability secondary to MS participated in a randomized crossover controlled study. Eleven subjects (8 female, 3 male; mean age [X±SD]=44±6 years) completed the study. After AT, but not NR, the subjects' walking distances and speeds during a self-paced walk were significantly improved, as were their maximum work rate, peak oxygen uptake, and oxygen pulse during cardiopulmonary exercise tests. The increases in peak oxygen uptake and maximum work rate, but not in walking capacity, were significantly higher after AT, as compared with after NR. Additionally, the subjects who were most disabled tended to benefit more from AT. There were no differences between AT and NR in effects on fatigue, and the results showed that AT may have partially affected health-related quality of life. The results suggest that AT is more effective than NR in improving maximum exercise tolerance and walking capacity in people with mild to moderate disability secondary to MS.
Physical deconditioning is involved in the impaired exercise tolerance of patients with multiple sclerosis (MS), but data on the effects of aerobic training (AT) in this population are scanty. The purpose of this study was to compare the effects of an 8-week AT program on exercise capacity-in terms of walking capacity and maximum exercise tolerance, as well as its effects on fatigue and health-related quality of life-as compared with neurological rehabilitation (NR) in subjects with MS.BACKGROUND AND PURPOSEPhysical deconditioning is involved in the impaired exercise tolerance of patients with multiple sclerosis (MS), but data on the effects of aerobic training (AT) in this population are scanty. The purpose of this study was to compare the effects of an 8-week AT program on exercise capacity-in terms of walking capacity and maximum exercise tolerance, as well as its effects on fatigue and health-related quality of life-as compared with neurological rehabilitation (NR) in subjects with MS.Nineteen subjects (14 female, 5 male; mean age [X+/-SD]=41+/-8 years) with mild to moderate disability secondary to MS participated in a randomized crossover controlled study. Eleven subjects (8 female, 3 male; mean age [X+/-SD]=44+/-6 years) completed the study.SUBJECTS AND METHODSNineteen subjects (14 female, 5 male; mean age [X+/-SD]=41+/-8 years) with mild to moderate disability secondary to MS participated in a randomized crossover controlled study. Eleven subjects (8 female, 3 male; mean age [X+/-SD]=44+/-6 years) completed the study.After AT, but not NR, the subjects' walking distances and speeds during a self-paced walk were significantly improved, as were their maximum work rate, peak oxygen uptake, and oxygen pulse during cardiopulmonary exercise tests. The increases in peak oxygen uptake and maximum work rate, but not in walking capacity, were significantly higher after AT, as compared with after NR. Additionally, the subjects who were most disabled tended to benefit more from AT. There were no differences between AT and NR in effects on fatigue, and the results showed that AT may have partially affected health-related quality of life.RESULTSAfter AT, but not NR, the subjects' walking distances and speeds during a self-paced walk were significantly improved, as were their maximum work rate, peak oxygen uptake, and oxygen pulse during cardiopulmonary exercise tests. The increases in peak oxygen uptake and maximum work rate, but not in walking capacity, were significantly higher after AT, as compared with after NR. Additionally, the subjects who were most disabled tended to benefit more from AT. There were no differences between AT and NR in effects on fatigue, and the results showed that AT may have partially affected health-related quality of life.The results suggest that AT is more effective than NR in improving maximum exercise tolerance and walking capacity in people with mild to moderate disability secondary to MS.DISCUSSION AND CONCLUSIONThe results suggest that AT is more effective than NR in improving maximum exercise tolerance and walking capacity in people with mild to moderate disability secondary to MS.
Background and Purpose: Physical deconditioning is involved in the impaired exercise tolerance of patients with multiple sclerosis (MS), but data on the effects of aerobic training (AT) in this population are scanty. The purpose of this study was to compare the effects of an 8-week AT program on exercise capacity--in terms of walking capacity and maximum exercise tolerance, as well as its effects on fatigue and health-related quality of life--as compared with neurological rehabilitation (NR) in subjects with MS. Subjects and Methods: Nineteen subjects (14 female, 5 male; mean age [x plus or minus SD]=41 plus or minus 8 years) with mild to moderate disability secondary to MS participated in a randomized crossover controlled study. Eleven subjects (8 female, 3 male; mean age [x plus or minus SD]=44 plus or minus 6 years) completed the study. Results: After AT, but not NR, the subjects' walking distances and speeds during a self-paced walk were significantly improved, as were their maximum work rate, peak oxygen uptake, and oxygen pulse during cardiopulmonary exercise tests. The increases in peak oxygen uptake and maximum work rate, but not in walking capacity, were significantly higher after AT, as compared with after NR. Additionally, the subjects who were most disabled tended to benefit more from AT. There were no differences between AT and NR in effects on fatigue, and the results showed that AT may have partially affected health-related quality of life. Discussion and Conclusion: The results suggest that AT is more effective than NR in improving maximum exercise tolerance and walking capacity in people with mild to moderate disability secondary to MS.
Audience Professional
Author Anais Rampello
Marco Franceschini
Massimo Piepoli
Gabriella Lenti
Roberto Antenucci
Dario Olivieri
Alfredo Chetta
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  surname: Rampello
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  surname: Piepoli
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  surname: Antenucci
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  givenname: Alfredo
  surname: Chetta
  fullname: Chetta, Alfredo
  organization: A Chetta, MD, is Associate Professor, Department of Clinical Sciences, Section of Respiratory Diseases, University of Parma, Viale G Rasori, 10–43100, Parma, Italy
BackLink https://www.ncbi.nlm.nih.gov/pubmed/17405806$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright COPYRIGHT 2007 Oxford University Press
Copyright American Physical Therapy Association May 2007
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Kileff (2019123111482343000_R34) 2005; 19
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Schubert (2019123111482343000_R8) 1998; 21
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17472954 - Phys Ther. 2007 May;87(5):555-8; author reply 558-9
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Snippet Physical deconditioning is involved in the impaired exercise tolerance of patients with multiple sclerosis (MS), but data on the effects of aerobic training...
Background and Purpose Physical deconditioning is involved in the impaired exercise tolerance of patients with multiple sclerosis (MS), but data on the effects...
Background and Purpose: Physical deconditioning is involved in the impaired exercise tolerance of patients with multiple sclerosis (MS), but data on the...
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StartPage 545
SubjectTerms Adult
Aerobic exercises
Care and treatment
Complications and side effects
Cross-Over Studies
Exercise
Exercise - physiology
Exercise Tolerance - physiology
Female
Health aspects
Heart Rate - physiology
Humans
Male
Mental Health
Multiple sclerosis
Multiple Sclerosis - physiopathology
Multiple Sclerosis - psychology
Multiple Sclerosis - rehabilitation
Oximetry
Oxygen Consumption - physiology
Physical fitness
Physical therapy
Quality of Life
Respiratory Function Tests
Surveys and Questionnaires
Walking
Walking - physiology
Title Effect of Aerobic Training on Walking Capacity and Maximal Exercise Tolerance in Patients With Multiple Sclerosis: A Randomized Crossover Controlled Study
URI http://ptjournal.apta.org/content/87/5/545.abstract
https://www.ncbi.nlm.nih.gov/pubmed/17405806
https://www.proquest.com/docview/223118376
https://www.proquest.com/docview/19706633
https://www.proquest.com/docview/70450395
https://www.proquest.com/docview/771806720
Volume 87
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