Resting state functional connectivity of the pain matrix and default mode network in irritable bowel syndrome: a graph theoretical analysis

• Published in: Scientific reports Vol. 10; no. 1; p. 11015
• Main Authors: Kano, Michiko, Grinsvall, Cecilia, Ran, Qian, Dupont, Patrick, Morishita, Joe, Muratsubaki, Tomohiko, Mugikura, Shunji, Ly, Huynh Giao, Törnblom, Hans, Ljungberg, Maria, Takase, Kei, Simrén, Magnus, Van Oudenhove, Lukas, Fukudo, Shin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.07.2020; Nature Publishing Group
• Subjects: 59/36; 631/378/2620/410/2610; 692/4020/1503/1502/2071; abdominal-pain; Anxiety; brain connectivity; Case-Control Studies; Connectome - methods; depression; Female; fmri; Humanities and Social Sciences; Humans; ibs; Intestine; Irritable bowel syndrome; Irritable Bowel Syndrome - diagnostic imaging; Irritable Bowel Syndrome - physiopathology; Magnetic Resonance Imaging; Male; multidisciplinary; Neural networks; Neurosciences; Neurovetenskaper; Pain; Pain - diagnostic imaging; Pain - physiopathology; parcellation; rectal distension; Rectum; Rest; scale; Science; Science & Technology - Other Topics; Science (multidisciplinary); Theoretical analysis; validation; visceral sensitivity; Young Adult

Irritable bowel syndrome (IBS) is a functional disorder of brain-gut interactions. Differential brain responses to rectal distention between IBS and healthy controls (HCs) have been demonstrated, particularly in the pain matrix and the default mode network. This study aims to compare resting-state f...