WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1

• Published in: Molecular cancer Vol. 18; no. 1; pp. 127 - 19
• Main Authors: Chen, Yunhao, Peng, Chuanhui, Chen, Junru, Chen, Diyu, Yang, Beng, He, Bin, Hu, Wendi, Zhang, Yanpeng, Liu, Hua, Dai, Longfei, Xie, Haiyang, Zhou, Lin, Wu, Jian, Zheng, Shusen
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.08.2019; BioMed Central; BMC
• Subjects: Animals; Antigens; Cancer; Cancer genetics; Cancer therapies; Carcinogenesis; Carcinoma; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - pathology; Care and treatment; Cell cycle; Cell Cycle - genetics; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell Line, Tumor; Cell proliferation; Cell Transformation, Neoplastic; Chromatin; Cyclin-dependent kinase inhibitor p21; Development and progression; Disease Models, Animal; DNA Methylation; DNA microarrays; ELAV-Like Protein 1 - metabolism; Enzymes; Epigenesis, Genetic; Epigenetic inheritance; Epigenetics; Ets-1 protein; ETS1; Female; Gene expression; Gene Silencing; Genes; Genetic aspects; Genomes; Genomics; Hepatocellular carcinoma; Hepatocellular carcinoma (HCC); Humans; HuR protein; Immunoprecipitation; Liver; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Luciferase; Male; Medical prognosis; Metastasis; Methylation; Methyltransferases; Methyltransferases - metabolism; Mice; Models, Biological; N6-methyladenosine; N6-methyladenosine (m6A); Neoplasm Staging; Nephroblastoma; Novels; Patient outcomes; Phenotypes; Post-transcription; Prognosis; Proteins; Proto-Oncogene Protein c-ets-1 - genetics; Ribonucleic acid; RNA; RNA sequencing; RNA Splicing Factors - genetics; RNA Splicing Factors - metabolism; Survival analysis; Therapeutic applications; Tumor Burden; Tumorigenesis; Tumors; Wilms tumor 1-associated protein (WTAP); Writers; WT1 protein; Xenograft Model Antitumor Assays; Xenografts; N6-methyladenosine (m6A); Wilms tumor 1-associated protein (WTAP); ETS1; Hepatocellular carcinoma (HCC)

N6-methyladenosine (m6A) methylation, a well-known modification with new epigenetic functions, has been reported to participate in the tumorigenesis of hepatocellular carcinoma (HCC), providing novel insights into the molecular pathogenesis of this disease. However, as the key component of m6A methy...