WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1 - Chen, Yunhao; Peng, Chuanhui; Chen, Junru; Chen, Diyu; Yang, Beng; He, Bin; Hu, Wendi; Zhang, Yanpeng; Liu, Hua; Dai, Longfei; Xie, Haiyang; Zhou, Lin; et al. (Molecular cancer, 2019)
Keywords: Animals; Antigens; Cancer; Cancer genetics; Cancer therapies; Carcinogenesis; Carcinoma; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - pathology; Care and treatment; Cell cycle; Cell Cycle - genetics; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell Line, Tumor; Cell proliferation; Cell Transformation, Neoplastic; Chromatin; Cyclin-dependent kinase inhibitor p21; Development and progression; Disease Models, Animal; DNA Methylation; DNA microarrays; ELAV-Like Protein 1 - metabolism; Enzymes; Epigenesis, Genetic; Epigenetic inheritance; Epigenetics; Ets-1 protein; ETS1; Female; Gene expression; Gene Silencing; Genes; Genetic aspects; Genomes; Genomics; Hepatocellular carcinoma; Hepatocellular carcinoma (HCC); Humans; HuR protein; Immunoprecipitation; Liver; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Luciferase; Male; Medical prognosis; Metastasis; Methylation; Methyltransferases; Methyltransferases - metabolism; Mice; Models, Biological; N6-methyladenosine; N6-methyladenosine (m6A); Neoplasm Staging; Nephroblastoma; Novels; Patient outcomes; Phenotypes; Post-transcription; Prognosis; Proteins; Proto-Oncogene Protein c-ets-1 - genetics; Ribonucleic acid; RNA; RNA sequencing; RNA Splicing Factors - genetics; RNA Splicing Factors - metabolism; Survival analysis; Therapeutic applications; Tumor Burden; Tumorigenesis; Tumors; Wilms tumor 1-associated protein (WTAP); Writers; WT1 protein; Xenograft Model Antitumor Assays; Xenografts; N6-methyladenosine (m6A); Wilms tumor 1-associated protein (WTAP); ETS1; Hepatocellular carcinoma (HCC)