Effects and mechanism of dexmedetomidine on neuronal cell injury induced by hypoxia-ischemia

• Published in: BMC anesthesiology Vol. 17; no. 1; pp. 117 - 10
• Main Authors: Liu, Ya-Jun, Wang, Duan-Yu, Yang, Yong-Jian, Lei, Wei-Fu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.08.2017; BioMed Central; BMC
• Subjects: Animals; Animals, Newborn; Apoptosis; BAX protein; Bcl protein; Bcl-2 protein; Care and treatment; Cell culture; Cell Hypoxia - drug effects; Cell Hypoxia - physiology; Cell injury; Cell Survival - drug effects; Cell Survival - physiology; Cells, Cultured; Cytokines; Cytoprotection - drug effects; Cytoprotection - physiology; Dexmedetomidine; Dexmedetomidine - pharmacology; Disease; Gene expression; Glucose - deficiency; Growth factors; Hypnotics and Sedatives - pharmacology; Hypoxia; Inflammation; Ischemia; Kinases; Leukemia; Male; Neurons - drug effects; Neurons - metabolism; Neurophysiology; Neurotrophic factors; Notch/NF-κB pathway; Oxidative stress; Oxygen - metabolism; PC12 Cells; Pheochromocytoma cells; Physiological aspects; Rats; Rats, Wistar; Rodents; Signal transduction; Stroke; Studies; United States > US; Oxidative stress; PC12 cells; Dexmedetomidine; Notch/NF-κB pathway; Apoptosis

The present study aims to investigate the protective effects of dexmedetomidine (DMED) on hypoxia ischemia injury induced by oxygen and glucose deprivation (OGD) in PC12 and primary neuronal cells. PC12 cells exposed to OGD was used to establish ischemia model. The OGD-induced cell injury was evalua...