Glucose-sensing microRNA-21 disrupts ROS homeostasis and impairs antioxidant responses in cellular glucose variability - La Sala, Lucia; Mrakic-Sposta, Simona; Micheloni, Stefano; Prattichizzo, Francesco; Ceriello, Antonio (Cardiovascular diabetology, 2018)
Keywords: 3' Untranslated Regions; Anions; Antioxidants; Antioxidants - metabolism; Apoptosis; Binding Sites; Cardiovascular disease; Cells, Cultured; Chemoreception; Diabetes; Diabetes mellitus; Diabetic retinopathy; Enzymes; Epigenetics; Forkhead Box Protein O1 - genetics; Forkhead Box Protein O1 - metabolism; FOXO1 protein; Gene expression; Gene Expression Regulation, Enzymologic; Glucose; Glucose - toxicity; Growth factors; Homeostasis; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - enzymology; Humans; Hyperglycemia; KRIT1; KRIT1 Protein - genetics; KRIT1 Protein - metabolism; Membrane potential; Membrane Potential, Mitochondrial - drug effects; Membrane proteins; Metabolism; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miR-21; miRNA; Mitochondria; Mitochondria - drug effects; Mitochondria - enzymology; Mitochondrial dysfunction; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; Original Investigation; Oxidative stress; Oxidative Stress - drug effects; Reactive oxygen species; Reactive Oxygen Species - metabolism; Rodents; ROS homeostasis; Signal Transduction - drug effects; SOD2; Superoxide; Superoxide anion; Superoxide anions; Superoxide dismutase; Superoxide Dismutase - genetics; Superoxide Dismutase - metabolism; Toxicity; Glucose variability; Superoxide anion; Mitochondrial dysfunction; ROS homeostasis; KRIT1; miR-21; SOD2; Oscillating glucose