Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 112; no. 6; pp. 1749 - 1754
• Main Authors: Batuello, Christopher N., Hauck, Paula M., Gendron, Jaimie M., Lehman, Jason A., Mayo, Lindsey D.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 10.02.2015; National Acad Sciences
• Subjects: Animals; Biological Sciences; Blotting, Western; Cell growth; Cell Line; Enzymes; Humans; Immunoprecipitation; Mass Spectrometry; Mice; NEDD8 Protein; Phosphorylation; Proteins; Proto-Oncogene Proteins c-mdm2 - metabolism; Signal Transduction - physiology; src-Family Kinases - metabolism; Tumors; Ubiquitination; Ubiquitins - metabolism; Mdm2; Src; Nedd8

Murine double minute-2 protein (Mdm2) is a multifaceted phosphorylated protein that plays a role in regulating numerous proteins including the tumor suppressor protein p53. Mdm2 binds to and is involved in conjugating either ubiquitin or Nedd8 (Neural precursor cell expressed, developmentally down-r...