The role of the bacterial protease Prc in the uropathogenesis of extraintestinal pathogenic Escherichia coli

• Published in: Journal of biomedical science Vol. 27; no. 1; pp. 14 - 22
• Main Authors: Huang, Wen-Chun, Lin, Chung-Yen, Hashimoto, Masayuki, Wu, Jiunn-Jong, Wang, Ming-Cheng, Lin, Wei-Hung, Chen, Chang-Shi, Teng, Ching-Hao
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.01.2020; BioMed Central; BMC
• Subjects: Accumulation; Analysis; Antibiotic resistance; Antibiotics; Attenuation; Bacteria; Bacterial infections; Bacterial proteins; Bladder; Cellular signal transduction; Characterization; Chromosomes; Colonization; Complement system; Deletion; Development and progression; Drug resistance; E coli; Escherichia coli; Extraintestinal pathogenic Escherichia coli; Flagella; Gene expression; Genes; Genetic research; Health aspects; Hydrolase; Infection; Kidneys; Kinases; Meningitis; Microbial drug resistance; Motility; Mutants; Neonates; Newborn infants; Novels; Pathogenesis; Pathogenic microorganisms; Pathogens; Peptidoglycan hydrolase; Plasmids; Protease; Protease Prc; Proteases; Proteins; Proteomics; RNA polymerase; Septicemia; Signal transduction; Signalling systems; Substrates; Time; Transcription; Urinary tract; Urinary tract infections; Urogenital system; Virulence; China; σE; Motility; Protease Prc; Spr; Urinary tract infections; Extraintestinal pathogenic Escherichia coli; Flagella; Two-component signal transduction system RcsCDB

Extraintestinal pathogenic E. coli (ExPEC) remains one of the most prevalent bacterial pathogens that cause extraintestinal infections, including neonatal meningitis, septicemia, and urinary tract (UT) infections (UTIs). Antibiotic therapy has been the conventional treatment for such infections, but...