Temporospatial gene expression of Prx1 and Prx2 is involved in morphogenesis of cranial placode-derived tissues through epithelio-mesenchymal interaction during rat embryogenesis

• Published in: Cell and tissue research Vol. 353; no. 1; pp. 27 - 40
• Main Authors: Higuchi, Masashi, Kato, Takako, Chen, Mo, Yako, Hideji, Yoshida, Saishu, Kanno, Naoko, Kato, Yukio
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.07.2013; Springer; Springer Nature B.V
• Subjects: Animals; Antibodies; Biomedical and Life Sciences; Biomedicine; Developmental biology; Embryo, Mammalian; Embryo, Mammalian - metabolism; embryogenesis; embryology; Embryonic Development; Embryos; Epithelial-Mesenchymal Transition; Epithelial-Mesenchymal Transition - genetics; Gene expression; Gene Expression Regulation, Developmental; Gene Knockout Techniques; Genetic research; genetics; heart; Homeodomain Proteins; Homeodomain Proteins - genetics; Human Genetics; in situ hybridization; metabolism; Molecular Medicine; morphogenesis; Morphogenesis - genetics; neural crest; Peptides; Polyclonal antibodies; proteins; Proteomics; Rats; Rats, Wistar; Regular Article; Skull; Skull - embryology; Skull - metabolism; SOXB1 Transcription Factors; SOXB1 Transcription Factors - metabolism; Stem cells; transcription factors; Transcription Factors - genetics; Japan; Development; PRX2; Embryo; Rat; Antibody; PRX1

Paired-related homeobox transcription factors, PRX1 and PRX2, are verified to play essential roles in limb, heart and craniofacial development by analyses of knockout animals. Their gene expression in the embryonic primordia derived from the mesoderm and neural crest is confirmed by in situ hybridiz...