Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor

• Published in: Molecular cell Vol. 58; no. 6; pp. 1040 - 1052
• Main Authors: Booe, Jason M., Walker, Christopher S., Barwell, James, Kuteyi, Gabriel, Simms, John, Jamaluddin, Muhammad A., Warner, Margaret L., Bill, Roslyn M., Harris, Paul W., Brimble, Margaret A., Poyner, David R., Hay, Debbie L., Pioszak, Augen A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.06.2015; Elsevier; Cell Press
• Subjects: Adrenomedullin - chemistry; Adrenomedullin - genetics; Adrenomedullin - metabolism; Amino Acid Sequence; Animals; BASIC BIOLOGICAL SCIENCES; Binding Sites - genetics; Calcitonin Gene-Related Peptide - chemistry; Calcitonin Gene-Related Peptide - genetics; Calcitonin Gene-Related Peptide - metabolism; Calcitonin Receptor-Like Protein - chemistry; Calcitonin Receptor-Like Protein - genetics; Calcitonin Receptor-Like Protein - metabolism; Chlorocebus aethiops; COS Cells; Crystallography, X-Ray; Humans; Models, Molecular; Molecular Sequence Data; Mutation; Peptides - chemistry; Peptides - genetics; Peptides - metabolism; Protein Binding; Protein Multimerization; Protein Structure, Secondary; Protein Structure, Tertiary; Receptor Activity-Modifying Protein 1 - chemistry; Receptor Activity-Modifying Protein 1 - genetics; Receptor Activity-Modifying Protein 1 - metabolism; Receptor Activity-Modifying Protein 2 - chemistry; Receptor Activity-Modifying Protein 2 - genetics; Receptor Activity-Modifying Protein 2 - metabolism; Sequence Homology, Amino Acid

Association of receptor activity-modifying proteins (RAMP1-3) with the G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) enables selective recognition of the peptides calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) that have diverse functions in the cardiovascu...